INT112927

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.31
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cords 2
brain 2
neural 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 90 100.00 Very High Very High Very High
mu opioid receptor 32 100.00 Very High Very High Very High
narcan 6 99.84 Very High Very High Very High
Morphine 136 99.64 Very High Very High Very High
tolerance 83 99.32 Very High Very High Very High
Kappa opioid receptor 7 99.08 Very High Very High Very High
tail-flick 9 96.28 Very High Very High Very High
Kinase C 42 95.84 Very High Very High Very High
Analgesic 83 95.32 Very High Very High Very High
Enkephalin 2 94.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 28 87.52 High High
Pain 7 69.64 Quite High
Nociception 10 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other mice were sacrificed at the end of the treatment and spinal cords were collected for determination of muOR density and GRK-2 and DYN-2 protein abundance.
Negative_regulation (determination) of Localization (abundance) of muOR density in spinal cords
1) Confidence 0.39 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 1.13
These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance.
Negative_regulation (inhibits) of Localization (recycling) of MOR associated with tolerance, mu opioid receptor, kappa opioid receptor and morphine
2) Confidence 0.38 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.07 Pain Relevance 2.29
These processes occur before repeated morphine administration leads to internalization and recycling of the neural MOR, a process mediated by GRKs and ?
Negative_regulation (process) of Localization (internalization) of MOR in neural associated with opioid receptor and morphine
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.08 Pain Relevance 1.25
In the brain, most cases of tolerance to morphine occur as a result of depletion of the MOR-regulated G proteins, which are transferred to RGS proteins belonging to the R7 and Rz subfamilies [25,47,48].
Negative_regulation (depletion) of Localization (transferred) of MOR-regulated in brain associated with tolerance and morphine
4) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.16 Pain Relevance 0.92

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox