INT112928

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cord 3
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 8 99.84 Very High Very High Very High
Immobilon 15 99.64 Very High Very High Very High
Spinal cord 15 99.60 Very High Very High Very High
opioid receptor 15 98.88 Very High Very High Very High
Opioid 6 97.92 Very High Very High Very High
tail-flick 1 94.52 High High
Morphine 7 92.16 High High
agonist 5 89.68 High High
MU agonist 11 87.64 High High
antagonist 10 86.72 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the present study examined the effect of various infusion doses of etorphine on muOR density, DYN-2 protein, and DYN-2 mRNA abundance in mouse spinal cord.
Localization (abundance) of DYN-2 mRNA in spinal cord associated with spinal cord and immobilon
1) Confidence 0.74 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.83
Therefore, the present study examined the effect of various infusion doses of etorphine on muOR density, DYN-2 protein, and DYN-2 mRNA abundance in mouse spinal cord.
Localization (abundance) of DYN-2 protein in spinal cord associated with spinal cord and immobilon
2) Confidence 0.74 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.84
These data indicate that mu-opioid receptor density, determined in radioligand binding assays, and immunoreactive dynamin-2 abundance are regulated by continuous, but not intermittent, opioid ligand treatment.
Localization (abundance) of immunoreactive dynamin-2 associated with opioid receptor and opioid
3) Confidence 0.56 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.02
Other mice were sacrificed at the end of the treatment and spinal cords were collected for determination of muOR density and GRK-2 and DYN-2 protein abundance.
Localization (abundance) of DYN-2 protein in spinal cords
4) Confidence 0.54 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 1.12

General Comments

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