INT112934

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.69
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
neurons 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 46 99.04 Very High Very High Very High
depression 19 98.84 Very High Very High Very High
antidepressant 18 98.80 Very High Very High Very High
fluoxetine 3 92.04 High High
Desipramine 3 91.48 High High
nud 2 75.00 Quite High
Inflammation 30 69.52 Quite High
agonist 25 56.16 Quite High
Bioavailability 2 25.00 Low Low
Hyperalgesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 26 99.32 Very High Very High Very High
Depression 19 98.84 Very High Very High Very High
Stress 65 95.04 Very High Very High Very High
Dyspepsia 2 75.00 Quite High
INFLAMMATION 31 69.52 Quite High
Hypopituitarism 1 43.68 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 38.28 Quite Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the association of CRHR1 genotypes with the phenotype of antidepressant treatment response in 80 depressed Mexican-Americans in Los Angeles who completed a prospective randomized, placebo lead-in, double-blind treatment of fluoxetine or desipramine, with active treatment for 8 weeks.
CRHR1 Binding (association) of associated with desipramine, antidepressant and fluoxetine
1) Confidence 0.46 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 0.48 Pain Relevance 0.39
Our preliminary evidence indicated a potentiating interaction between CRF-CRF1 pathways and estrogen in the stimulation of colonic motor responses that may take place within the enteric neurons of the colon, where both CRF1 and estrogen receptors are present.
CRF-CRF1 Binding (interaction) of in neurons
2) Confidence 0.37 Published 2005 Journal Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University Section Body Doc Link 16290887 Disease Relevance 0 Pain Relevance 0
Our preliminary evidence indicated a potentiating interaction between CRF-CRF1 pathways and estrogen in the stimulation of colonic motor responses that may take place within the enteric neurons of the colon, where both CRF1 and estrogen receptors are present.
CRF-CRF1 Binding (interaction) of in neurons
3) Confidence 0.37 Published 2005 Journal Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University Section Body Doc Link 16290887 Disease Relevance 0 Pain Relevance 0
In those with lower-anxiety levels at screening, there were no associations between CRHR1 genotype and percent change in HAM-A or HAM-D.
CRHR1 Neg (no) Binding (associations) of associated with anxiety disorder
4) Confidence 0.36 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 0.84 Pain Relevance 0.38
Utilizing the haplotype-tag single-nucleotide polymorphisms rs1876828, rs242939 and rs242941, we tested for haplotypic association between CRHR1 and 8-week response to daily antidepressant treatment.
CRHR1 Binding (association) of associated with antidepressant
5) Confidence 0.36 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 1.03 Pain Relevance 0.43
A novel water-soluble tricyclic CRF1 antagonist, NBI 35965 was developed that displayed a high affinity for CRF1 (Ki approximately 4 nM) while having no binding affinity to CRF2.
CRF1 Binding (affinity) of associated with antagonist
6) Confidence 0.31 Published 2003 Journal Brain Res. Section Abstract Doc Link 12957366 Disease Relevance 0.33 Pain Relevance 0.17
CRH and the different urocortin peptides bind with similar affinity to the CRH1-R, but the affinity of urocortin for the CRH2-R is much higher than that of CRH, whereas urocortin II has no affinity for CRH1-R (590).
CRH1-R Binding (bind) of
7) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03

General Comments

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