INT112940

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.85
Pain Relevance 10.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
ganglion cells 3
spinal cord 2
brain 2
heart 2
amacrine cells 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 168 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
Kappa opioid receptor 7 99.84 Very High Very High Very High
Intracerebroventricular 1 99.80 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
Pain 18 99.54 Very High Very High Very High
Opioid 4 98.72 Very High Very High Very High
Analgesic 6 98.36 Very High Very High Very High
Antinociceptive 5 98.36 Very High Very High Very High
tolerance 39 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 33 100.00 Very High Very High Very High
Virus Diseases 94 99.98 Very High Very High Very High
Targeted Disruption 28 99.64 Very High Very High Very High
Pain 14 99.54 Very High Very High Very High
Parkinson's Disease 116 99.28 Very High Very High Very High
Neuropathic Pain 6 97.20 Very High Very High Very High
Hyperalgesia 24 96.76 Very High Very High Very High
Diabetes Mellitus 36 96.56 Very High Very High Very High
Infection 24 96.28 Very High Very High Very High
INFLAMMATION 130 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-tolerant mice showed an activation of PKC within the brain, which was suppressed by pretreatment with chelerythrine (1 nmol, i.c.v.).
Negative_regulation (suppressed) of Positive_regulation (activation) of PKC in brain associated with kinase c and morphine
1) Confidence 0.45 Published 2007 Journal Neuroscience Section Abstract Doc Link 17681696 Disease Relevance 0 Pain Relevance 1.69
In the present study, we investigated whether a gene deletion for an endogenous mu-opioid peptide beta-endorphin could affect pain-like behavior and the suppression of the morphine-induced rewarding effect by the direct activation of PKC in the spinal cord.
Negative_regulation (suppression) of Spec (whether) Positive_regulation (activation) of PKC in spinal cord associated with pain, kinase c, opioid, spinal cord and morphine
2) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18262361 Disease Relevance 0.83 Pain Relevance 1.94
We have previously reported that intracerebroventricular (i.c.v.) injection of either a PKC or PKA inhibitor completely reversed the expression of 5- to 8-fold morphine antinociceptive tolerance.
Negative_regulation (reversed) of Positive_regulation (injection) of PKC associated with tolerance, antinociceptive, intracerebroventricular and morphine
3) Confidence 0.41 Published 2003 Journal Brain Res. Section Abstract Doc Link 12957370 Disease Relevance 0 Pain Relevance 0.97
Altogether, these data indicate that BDV interferes with PKC signaling downstream of PKC activation.
Negative_regulation (interferes) of Positive_regulation (activation) of PKC associated with virus diseases and kinase c
4) Confidence 0.34 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.99 Pain Relevance 0.68
It should be noted that a single i.t. injection of BDNF produced a long-lasting thermal hyperalgesia and tactile allodynia in normal mice, and these responses were abolished by i.t. pre-treatment with either a Trk-dependent tyrosine kinase inhibitor K-252a or a selective protein kinase C (PKC) inhibitor Ro-32-0432.
Negative_regulation (inhibitor) of Positive_regulation (selective) of PKC associated with brush evoked pain, kinase c and thermal hyperalgesia
5) Confidence 0.31 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836617 Disease Relevance 0.64 Pain Relevance 0.91
Involvement of kappa opioid receptors in the inhibition of receptor desensitization and PKC activation induced by repeated morphine treatment.
Negative_regulation (inhibition) of Positive_regulation (activation) of PKC associated with kappa opioid receptor and morphine
6) Confidence 0.30 Published 2008 Journal J. Pharm. Pharmacol. Section Title Doc Link 18718122 Disease Relevance 0.09 Pain Relevance 2.04
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of Neg (not) Positive_regulation (not) of PKC in ganglion cells associated with ganglion cysts
7) Confidence 0.23 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
However, statins inhibit PKC activation, increasing the pool of unphosphorylated transrepression-competent PPAR?
Negative_regulation (inhibit) of Positive_regulation (activation) of PKC associated with kinase c
8) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.76 Pain Relevance 0.41
The fact that only PKC activation leads to the reduction of temperature threshold for TRPV1 activation might be pertinent to this issue.
Negative_regulation (reduction) of Positive_regulation (activation) of PKC
9) Confidence 0.13 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.20 Pain Relevance 0.36
In addition, the hippocampal slices of Ng knockout mice displayed a reduced activation of Ca2+/CaM-dependent kinase II (CaMKII) and PKC isozymes, as well as PKA.
Negative_regulation (reduced) of Positive_regulation (activation) of PKC associated with targeted disruption and kinase c
10) Confidence 0.11 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.56 Pain Relevance 0.41
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of in amacrine cells Neg (not) Positive_regulation (not) of PKC in ganglion cells associated with ganglion cysts
11) Confidence 0.08 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
In the presence of diabetes, several factors may alter NO availability: increased production of oxygen free radicals, increased levels of asymmetric dimethylarginine (ADMA), which is an irreversible inhibitor of NOS, activation of protein-kinase C (PKC), and accelerated production of advanced products of glycosilation (AGEs) (Brownlee 1992; Surdacki et al 2007).
Negative_regulation (inhibitor) of Positive_regulation (activation) of PKC associated with kinase c and diabetes mellitus
12) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.64 Pain Relevance 0.13
Baines et al. have reported that the MPTP of isolated heart mitochondria was inhibited following incubation for 15 min with purified PKC?
Negative_regulation (inhibited) of Positive_regulation (incubation) of PKC in heart associated with parkinson's disease and kinase c
13) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.76 Pain Relevance 0.13

General Comments

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