INT112947

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il1r1) plasma membrane (Il1r1) intracellular (Il1r1)
protein complex (Il1r1) signal transducer activity (Il1r1)
Anatomy Link Frequency
SCI 1
Il1r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.72 Very High Very High Very High
Glutamate 3 92.24 High High
intrathecal 6 90.24 High High
anesthesia 2 55.68 Quite High
cytokine 4 5.36 Low Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 9 84.60 Quite High
Overactive Bladder 3 75.00 Quite High
Frailty 1 75.00 Quite High
Injury 1 51.92 Quite High
Shock 7 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glycine level of the lumbosacral cord was 54% lower in chronic SCI rats when compared with intact rats, while the GlyR alpha1 mRNA level did not change after SCI.
Neg (not) Regulation (change) of GlyR alpha1 in SCI associated with spinal cord
1) Confidence 0.24 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 12957506 Disease Relevance 0.20 Pain Relevance 0.78
Other significantly up-regulated pathways present in the HFG females and not in the males, included those involved in cell proliferation/nutrient sensation (mtor, tall1), immune activity (nkt, il1R), energy regulation (ketonebodies, malate, Vitcb) and subcellular trafficking (TRANSPORT, cbl).
Regulation (regulation) of il1R
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.16 Pain Relevance 0

General Comments

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