INT112949

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
leukocyte 2
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 80 95.60 Very High Very High Very High
Angina 2 73.52 Quite High
cva 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Cv Unclassified Under Development 80 95.60 Very High Very High Very High
Injury 5 95.12 Very High Very High Very High
Acute Renal Failure 2 87.16 High High
Myocardial Infarction 2 78.68 Quite High
Death 1 75.12 Quite High
Coronary Artery Disease 1 75.00 Quite High
Cv General 3 Under Development 2 73.52 Quite High
Poisoning 3 23.84 Low Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative risk associated with the highest compared with the lowest thirds of ICAM-1 (>625 versus <502 ng/ml) was 2.45 (95% CI: 1.64-3.65, P<0.001) without adjustment; it decreased moderately (RR: 2.09; 95% CI: 1.34-3.24, P<0.001) after control for lipid and non-lipid factors and remained significantly elevated after adjustment for C-reactive protein (CRP) (RR: 1.90; 95% CI: 1.21-2.96, P=0.005).
Negative_regulation (decreased) of ICAM-1 Binding (associated) of
1) Confidence 0.24 Published 2003 Journal Atherosclerosis Section Abstract Doc Link 12957696 Disease Relevance 0.69 Pain Relevance 0.13
NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [22,24].
Negative_regulation (decreasing) of ICAM-1 Binding (binding) of in leukocyte associated with adhesions
2) Confidence 0.19 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 1.06 Pain Relevance 0.34

General Comments

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