INT112962

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 10.63
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
astrocytes 4
macrophages 1
microglia 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 195 99.92 Very High Very High Very High
antagonist 16 99.70 Very High Very High Very High
Inflammatory response 46 98.52 Very High Very High Very High
Paracetamol 9 98.28 Very High Very High Very High
ischemia 35 93.20 High High
COX2 3 91.60 High High
Inflammation 331 85.60 High High
Intracerebroventricular 1 77.48 Quite High
Inflammatory mediators 7 75.96 Quite High
cytokine 85 72.52 Quite High
Disease Link Frequency Relevance Heat
Obesity 168 100.00 Very High Very High Very High
Disease 92 100.00 Very High Very High Very High
Diabetes Mellitus 91 99.84 Very High Very High Very High
Cancer 130 99.36 Very High Very High Very High
INFLAMMATION 400 98.16 Very High Very High Very High
Multiple Myeloma 1 96.84 Very High Very High Very High
Coronary Stenosis 1 96.20 Very High Very High Very High
Cv Unclassified Under Development 31 93.20 High High
Disorder Of Lipid Metabolism 313 92.28 High High
Nephrotoxicity 3 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of peroxisome proliferator receptor (PPAR)-alpha activation in diabetes, in protection against lethal acetaminophen (APAP) challenge, was investigated.
Spec (investigated) Regulation (role) of Spec (investigated) Positive_regulation (activation) of PPAR associated with paracetamol and diabetes mellitus
1) Confidence 0.45 Published 2003 Journal FASEB J. Section Abstract Doc Link 12958197 Disease Relevance 1.09 Pain Relevance 0.43
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (important) of Positive_regulation (gene) of PPAR associated with obesity
2) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (regulatory) of Positive_regulation (gene) of PPAR associated with obesity
3) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0
Another possible explanation for these findings, raised by the authors, is that homeostasis cholesterol control by activation of PPAR?
Regulation (control) of Positive_regulation (activation) of PPAR
4) Confidence 0.44 Published 2008 Journal Thromb J Section Body Doc Link PMC2396603 Disease Relevance 0.38 Pain Relevance 0.03
Effect of PPAR activation on macrophages, microglia, and astrocytes
Regulation (Effect) of Positive_regulation (activation) of PPAR in astrocytes
5) Confidence 0.41 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.93 Pain Relevance 0.33
verify our conclusions that activation of PPAR?
Regulation (verify) of Positive_regulation (activation) of PPAR
6) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.17 Pain Relevance 0.07
ligand-dependent activation between human and mouse PPAR?
Regulation (ligand) of Positive_regulation (activation) of PPAR
7) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.35 Pain Relevance 0.08
ligand-dependent activation between human and mouse PPAR?
Regulation (dependent) of Positive_regulation (activation) of PPAR
8) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.35 Pain Relevance 0.08
The importance of these activities for the disease altering actions of PPAR
Regulation (importance) of Positive_regulation (actions) of PPAR associated with disease
9) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2465016 Disease Relevance 0.45 Pain Relevance 0.18
The importance of VLCFA-CoAs in activation of PPAR?
Regulation (importance) of Positive_regulation (activation) of PPAR
10) Confidence 0.38 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
antagonist) indicating a direct involvement of PPAR?
Regulation (direct) of Positive_regulation (involvement) of PPAR associated with antagonist
11) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.47 Pain Relevance 0.42
Thus, fenofibrate influences obesity via the differential activation of PPAR?.
Regulation (influences) of Positive_regulation (activation) of PPAR associated with obesity
12) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.87 Pain Relevance 0
Increased levels of chaperones might allow tight control of the inducibility of PPAR?.
Spec (might) Regulation (control) of Positive_regulation (inducibility) of PPAR
13) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.38 Pain Relevance 0
ligand on STAT3 activity depend directly on the expression and activation of PPAR-?
Regulation (depend) of Positive_regulation (activation) of PPAR
14) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.36 Pain Relevance 0.14
Reflecting the ability of statins and fibrates to synergistically activate PPAR?
Regulation (Reflecting) of Positive_regulation (activate) of PPAR
15) Confidence 0.24 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.83 Pain Relevance 0
To study the effect of the PPAR activation on cell proliferation,
Regulation (effect) of Positive_regulation (activation) of PPAR
16) Confidence 0.20 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0 Pain Relevance 0
Importantly, 5,11,14 20:3 did not affect transactivation of human PPAR?
Neg (not) Regulation (affect) of Positive_regulation (transactivation) of PPAR
17) Confidence 0.16 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.34 Pain Relevance 0.14
Effect of PPAR activation on macrophages, microglia, and astrocytes
Regulation (Effect) of in microglia Positive_regulation (activation) of PPAR in astrocytes
18) Confidence 0.14 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.93 Pain Relevance 0.33
Effect of PPAR activation on macrophages, microglia, and astrocytes
Regulation (Effect) of in macrophages Positive_regulation (activation) of PPAR in astrocytes
19) Confidence 0.14 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.93 Pain Relevance 0.33

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