INT112963

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.29
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 125 98.48 Very High Very High Very High
agonist 133 98.36 Very High Very High Very High
Paracetamol 8 98.28 Very High Very High Very High
COX-2 inhibitor 3 94.48 High High
cytokine 6 93.84 High High
addiction 2 73.60 Quite High
Bile 7 60.88 Quite High
Bioavailability 12 56.36 Quite High
cINOD 17 47.48 Quite Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 105 99.84 Very High Very High Very High
Cancer 261 99.76 Very High Very High Very High
Metastasis 22 98.92 Very High Very High Very High
INFLAMMATION 147 98.48 Very High Very High Very High
Colorectal Cancer 23 93.52 High High
Death 25 93.00 High High
Metabolic Syndrome 35 91.04 High High
Obesity 25 87.68 High High
Apoptosis 55 85.52 High High
Disorder Of Lipid Metabolism 200 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fenofibric acid derivatives exert their primary effects on lipid metabolism via the activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Regulation (effects) of Positive_regulation (activation) of PPAR
1) Confidence 0.44 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.08 Pain Relevance 0.08
regulates the activity of iNOS and activation of this PPAR
Regulation (regulates) of Positive_regulation (activation) of PPAR
2) Confidence 0.43 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.97 Pain Relevance 0.57
Data from recent major clinical trials have shown that fibrates produce beneficial effects on atherogenic lipoproteins through activation of PPAR?
Regulation (effects) of Positive_regulation (activation) of PPAR
3) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.81 Pain Relevance 0
The regulatory role of PPAR?
Regulation (regulatory) of Positive_regulation (role) of PPAR
4) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.50 Pain Relevance 0
The largest domain is the LBD located at the C-terminus [15], which is responsible for the binding of a specific ligand to PAR receptors, and subsequent activation of PPAR through binding to peroxisome proliferators response elements (PPREs) on the promoter region of the target genes.
Regulation (responsible) of Positive_regulation (activation) of PPAR
5) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.12 Pain Relevance 0
ligands exert antitumor properties did not determine whether the effects required ligand activation of the PPAR?
Regulation (ligand) of Positive_regulation (activation) of PPAR
6) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.45 Pain Relevance 0.12
synergistic effect with the thiazolidinediones in the activation of PPAR?
Regulation (effect) of Positive_regulation (activation) of PPAR
7) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.76 Pain Relevance 0.14
Fenofibric acid derivatives exert their primary effects on lipid metabolism via the activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Regulation (effects) of Positive_regulation (activation) of peroxisome proliferator-activated receptor-alpha
8) Confidence 0.30 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.08 Pain Relevance 0.08
belong to the pathway of metabolism and lipid transport, the target genes mediating the pro- or anti-cancer activity by affect of the activated PPAR?
Regulation (affect) of Positive_regulation (activated) of PPAR associated with cancer
9) Confidence 0.12 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.43 Pain Relevance 0
The role of peroxisome proliferator receptor (PPAR)-alpha activation in diabetes, in protection against lethal acetaminophen (APAP) challenge, was investigated.
Spec (investigated) Regulation (role) of Spec (investigated) Positive_regulation (activation) of peroxisome proliferator receptor associated with paracetamol and diabetes mellitus
10) Confidence 0.06 Published 2003 Journal FASEB J. Section Abstract Doc Link 12958197 Disease Relevance 1.09 Pain Relevance 0.43

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