INT112967

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 13.03
Pain Relevance 8.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
spinal nerve 1
astrocyte 1
lung 1
primary sensory neurons 1
microglia 1
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 307 100.00 Very High Very High Very High
chemokine 84 100.00 Very High Very High Very High
Inflammatory marker 1 100.00 Very High Very High Very High
cytokine 274 99.80 Very High Very High Very High
metalloproteinase 77 99.64 Very High Very High Very High
Infliximab 109 99.52 Very High Very High Very High
psoriasis 80 99.48 Very High Very High Very High
tetrodotoxin 7 98.64 Very High Very High Very High
Neuropathic pain 61 98.28 Very High Very High Very High
methotrexate 13 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 337 100.00 Very High Very High Very High
Disease 214 100.00 Very High Very High Very High
Asthma 33 100.00 Very High Very High Very High
Psoriasis 86 99.84 Very High Very High Very High
Nervous System Injury 32 99.70 Very High Very High Very High
Diabetes Mellitus 37 99.22 Very High Very High Very High
Neuropathic Pain 69 98.28 Very High Very High Very High
Autism 67 97.92 Very High Very High Very High
Injury 39 97.64 Very High Very High Very High
Burns 4 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MATERIALS AND METHODS: We examined the effects of ginsenoside Rb1 on the histamine, SP, and MCP-1 levels in burn wound tissue during burn wound repair.
Spec (examined) Regulation (effects) of MCP-1
1) Confidence 0.54 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18329832 Disease Relevance 0.48 Pain Relevance 0
and MCP-1, as well as other pro-inflammatory molecules may play a role in inhibiting microglial phagocytosis of fibrillar A?
Spec (may) Regulation (role) of MCP-1 associated with inflammation
2) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 1.33 Pain Relevance 0.42
Nonparametric Kendall tau correlation coefficients were derived for the relationships between lesion size and MCP-1 concentrations in ApoE?
Regulation (concentrations) of MCP-1
3) Confidence 0.24 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.27 Pain Relevance 0.22
The qRT-PCR analysis of these samples verified results for Ccl8 and indicated a down-regulation of 10 other asthma-related genes (Arg1, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2) in EOO versus AOO mice (Table 2).
Regulation (regulation) of Mcpt1 associated with asthma
4) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.44 Pain Relevance 0.15
Importantly, astrocyte production of inflammatory cytokines was observed, including production of cytokines known to affect various neuronal functions such as TNF-alpha and MCP-1.
Regulation (affect) of MCP-1 in astrocyte associated with inflammation and cytokine
5) Confidence 0.17 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 1.39 Pain Relevance 0.50
Nerve injury induces an up-regulation of the chemokine MCP-1 in primary sensory neurons [48,52].
Regulation (regulation) of MCP-1 in primary sensory neurons associated with chemokine and nervous system injury
6) Confidence 0.14 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.86 Pain Relevance 0.77
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Regulation (effect) of MCP1 in lung
7) Confidence 0.12 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.44 Pain Relevance 0.25
MCP-1 and oxLDL values are close to origin, indicating a lack of correlation between these values and any of the other variables.
Regulation (values) of MCP-1
8) Confidence 0.11 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.23 Pain Relevance 0.23
The lack of a positive correlation between radicals and these markers of inflammation, as well as between clinical parameters known to be associated with increased radical production, indicates that the possible hypoperfusion that occurs during carotid endarterectomy, and which is responsible for radical production, is not enhanced enough to cause cerebral inflammation, resulting in increased ICAM-1 and MCP-1 values.
Regulation (values) of MCP-1 associated with inflammation
9) Confidence 0.11 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.78 Pain Relevance 0.33
Up-regulation of the chemokines KC, MCP-1, and TNF-?
Regulation (regulation) of MCP-1 associated with chemokine
10) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.62 Pain Relevance 0.34
was less affected by decreases in intracellular calcium than MCP-1 and IL-6, and further implicates TNF-?
Regulation (affected) of MCP-1
11) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.83
As expected, several proinflammatory cytokines and chemokines such as IL-6 and MCP-1 are highly up-regulated by 2 h p.i..
Regulation (regulated) of MCP-1 associated with chemokine and cytokine
12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724709 Disease Relevance 1.18 Pain Relevance 0.39
Next, to determine whether down regulation of MCP-1, IL-6 and TNF-?
Spec (whether) Regulation (regulation) of MCP-1
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.30
Since chemokines may be released into CSF from inflamed spinal nerve roots, we studied the concentrations of the chemokines MCP-1, MIP-1beta, MIP-3beta, IP-10, SDF-1alpha, RANTES, and SLC in the CSF by sandwich ELISA in patients over the course of GBS and CIDP, before and after immunomodulatory treatment.
Regulation (concentrations) of MCP-1 in spinal nerve associated with chemokine, chronic inflammatory demyelinating polyradiculoneuropathy and syndrome
14) Confidence 0.04 Published 2003 Journal J. Clin. Immunol. Section Abstract Doc Link 12959218 Disease Relevance 1.27 Pain Relevance 0.44
In patients with type 2 diabetes higher soluble RAGE levels positively correlate with other inflammatory markers such as MCP-1, TNF-?
Regulation (correlate) of MCP-1 associated with diabetes mellitus and inflammatory marker
15) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.88 Pain Relevance 0.40
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of MCP-1 in microglia
16) Confidence 0.03 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.68
and the chemokine MCP-1 were not affected at doses of PPI-2458 up to 10 nmol/l (Figure 8a–d).
Neg (not) Regulation (affected) of chemokine MCP-1 associated with chemokine
17) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 0.61 Pain Relevance 0.46
At a molecular level, infliximab has been shown to down regulate disease-promoting chemokines such as interleukin 8, GRO-alpha and MCP-1 in pustular psoriasis (Benoit et al 2004).
Regulation (regulate) of MCP-1 associated with psoriasis, chemokine, infliximab and disease
18) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643098 Disease Relevance 1.25 Pain Relevance 0.88

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox