INT112969

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 20.17
Pain Relevance 10.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
choroid 3
mast cell 2
sensory neurons 1
myocardium 1
plasma 1
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 673 100.00 Very High Very High Very High
chemokine 115 100.00 Very High Very High Very High
Nerve growth factor 28 100.00 Very High Very High Very High
Thermal hyperalgesia 1 99.90 Very High Very High Very High
cytokine 433 99.72 Very High Very High Very High
Eae 8 99.68 Very High Very High Very High
Morphine 241 99.56 Very High Very High Very High
Inflammatory response 60 99.08 Very High Very High Very High
Etanercept 11 95.60 Very High Very High Very High
COX-2 inhibitor 6 92.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 674 100.00 Very High Very High Very High
Asthma 116 100.00 Very High Very High Very High
Uveitis 215 99.90 Very High Very High Very High
Hyperalgesia 4 99.90 Very High Very High Very High
Obesity 46 99.68 Very High Very High Very High
Injury 34 99.68 Very High Very High Very High
Hyperplasia 8 99.62 Very High Very High Very High
Hypertension 42 99.60 Very High Very High Very High
Syndrome 10 98.64 Very High Very High Very High
Nicotine Addiction 139 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (decreased) of MCP-1 in retina
1) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.15 Pain Relevance 0.41
In the EPA-treated animals, retinal MCP-1 (76.6±23.6 pg/mg total protein, n=7) was significantly decreased by 48.2% at 24 h after LPS injection, compared to the vehicle-treated EIU animals (148±10.2 pg/mg, n=6, p<0.05; Figure 3A).
Negative_regulation (decreased) of MCP-1 associated with uveitis
2) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.85 Pain Relevance 0.13
The qRT-PCR analysis of these samples verified results for Ccl8 and indicated a down-regulation of 10 other asthma-related genes (Arg1, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2) in EOO versus AOO mice (Table 2).
Negative_regulation (down-regulation) of Mcpt1 associated with asthma
3) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.44 Pain Relevance 0.15
Among the up-regulated genes were 3 associated with inhibition of proliferation (Gpnmb, Setd8, Runx2) and 1 promoting inflammatory and immune responses (Pik3cd), as well as 4 asthma-related genes (Arg1, Ccl24, Slc7a2, Mcpt1) identifiable only through qRT-PCR.
Negative_regulation (inhibition) of Mcpt1 associated with asthma and inflammation
4) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.57 Pain Relevance 0.19
Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
Negative_regulation (regulation) of Mcpt1 associated with asthma, nicotine addiction and inflammation
5) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.15 Pain Relevance 0.50
In contrast, protein levels of MCP-1 in the RPE-choroid complex were significantly decreased by 31.9% in the EPA-treated animals (353.3±36.2 pg/mg, n=8, p<0.05; Figure 4A).
Negative_regulation (decreased) of MCP-1 in choroid
6) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.90 Pain Relevance 0.08
The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice.
Negative_regulation (decreased) of MCP-1
7) Confidence 0.32 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19439982 Disease Relevance 0.42 Pain Relevance 0
In fact, the observed reduction of NGF, MCP-1, and IL-6 mRNAs in the DMSO-treated bladders could suggest the inhibitory effect of DMSO on abnormal activation of sensory neurons, urothelial cells, mast cells, and detrusor muscle cells.
Negative_regulation (reduction) of MCP-1 in urothelial cells associated with nerve growth factor and overactive bladder
8) Confidence 0.20 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.90 Pain Relevance 0.29
Interestingly, T cell deficiency was associated with less thermal hyperalgesia and reduced mRNA levels for the macrophage marker molecule F4/80 and the chemokine macrophage chemoattractant protein-1 (MCP-1) after CCI.
Negative_regulation (reduced) of MCP-1 in F4/80 associated with chemokine, eae and thermal hyperalgesia
9) Confidence 0.19 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.98 Pain Relevance 0.84
and MCP-1, were also markedly reduced in the adipose tissue of the Rx-treated mice (figure 7c, d).
Negative_regulation (reduced) of MCP-1 in adipose tissue associated with obesity
10) Confidence 0.18 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.90 Pain Relevance 0.29
, RANTES, and MCP-1 was reduced in Fc?
Negative_regulation (reduced) of MCP-1
11) Confidence 0.17 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.64 Pain Relevance 0.45
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (decreased) of MCP-1 in choroid
12) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.15 Pain Relevance 0.41
To investigate whether supplemental EPA may suppress inflammatory molecules in the uveal tissue during EIU, we measured MCP-1, IL-6, and ICAM-1 in the RPE-choroid complex.
Negative_regulation (measured) of MCP-1 in choroid associated with inflammation and uveitis
13) Confidence 0.14 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.97 Pain Relevance 0.15
, MCP-1, and IL-6 in medium were decreased at 12 and 24 h during LPS exposure by dobutamine and terbutaline (p < 0.01 respectively) as where levels of MCP-1 at 24 and 48 h following LPS + OGD (p < 0.01 respectively).
Negative_regulation (decreased) of MCP-1
14) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.17 Pain Relevance 0.45
Supernatants from astrocytes treated with Tat±morphine showed a significant decrease in MCP-1 IL-6 and TNF-?
Negative_regulation (decrease) of MCP-1 in astrocytes associated with morphine
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.80
We also noted that the lower concentrations of parthenolide reduced MCP-1, IL-6 and TNF-?
Negative_regulation (reduced) of MCP-1
16) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.11 Pain Relevance 0.47
release, but only partially inhibited IL-6 and MCP-1 mRNA levels, suggesting the possibility that TNF-?
Negative_regulation (inhibited) of MCP-1
17) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.11 Pain Relevance 0.51
These observations have been extended by Fulgenzi et al. [16] who demonstrated reduced IL-10, MCP-1 and IL-8 levels in inflamed vessels following FCA injection into rat paw following local use of periodate oxidised ATP (oATP).
Negative_regulation (reduced) of MCP-1 in paw
18) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.23 Pain Relevance 0.23
In fact, the observed reduction of NGF, MCP-1, and IL-6 mRNAs in the DMSO-treated bladders could suggest the inhibitory effect of DMSO on abnormal activation of sensory neurons, urothelial cells, mast cells, and detrusor muscle cells.
Negative_regulation (reduction) of MCP-1 in sensory neurons associated with nerve growth factor and overactive bladder
19) Confidence 0.07 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.90 Pain Relevance 0.29
In fact, the observed reduction of NGF, MCP-1, and IL-6 mRNAs in the DMSO-treated bladders could suggest the inhibitory effect of DMSO on abnormal activation of sensory neurons, urothelial cells, mast cells, and detrusor muscle cells.
Negative_regulation (reduction) of MCP-1 in mast cells associated with nerve growth factor and overactive bladder
20) Confidence 0.07 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.90 Pain Relevance 0.29

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