INT112970

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.77
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
spinal nerve 1
dendritic cell 1
T-cell 1
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 266 100.00 Very High Very High Very High
rheumatoid arthritis 99 99.96 Very High Very High Very High
Inflammation 190 99.64 Very High Very High Very High
Arthritis 47 99.42 Very High Very High Very High
Demyelination 24 98.20 Very High Very High Very High
cytokine 119 97.40 Very High Very High Very High
Central nervous system 100 95.92 Very High Very High Very High
Neuritis 13 92.12 High High
Rheumatism 2 92.10 High High
Neurotransmitter 2 91.28 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 99.96 Very High Very High Very High
Hantavirus Infection 18 99.86 Very High Very High Very High
INFLAMMATION 178 99.64 Very High Very High Very High
Seronegative Spondarthritis 12 99.42 Very High Very High Very High
Adhesions 19 99.32 Very High Very High Very High
Airway Obstruction 46 98.38 Very High Very High Very High
Demyelinating Disease 156 98.20 Very High Very High Very High
Sprains And Strains 83 97.90 Very High Very High Very High
Respiratory Syncytial Virus 218 97.68 Very High Very High Very High
Syndrome 21 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During evolution of lesions, these cells down-regulate CCR1 while retain the CCR5 expression.
Regulation (regulate) of CCR1
1) Confidence 0.29 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.67 Pain Relevance 0.18
Because the RANTES promoter is a target for the transcription factor NF-?
Regulation (target) of RANTES promoter
2) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0 Pain Relevance 0
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of CCR1 associated with chemokine, adhesions and cytokine
3) Confidence 0.23 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.07 Pain Relevance 0.23
These studies underscore the importance of CCR1 and CCR2 in the development of inflammatory demyelination and give support to novel alternative strategies targeting these CCR molecules.
Regulation (importance) of CCR1 associated with demyelination and inflammation
4) Confidence 0.18 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.10 Pain Relevance 0.28
RANTES regulated on activation, normal T-cell expressed and secreted
Regulation (regulated) of RANTES in T-cell
5) Confidence 0.06 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 0.53 Pain Relevance 0.05
During the acute phase in both mouse strains, airway obstruction (AO) peaked on day 5 and strongly correlated with histopathologic scores (HPS), BAL concentrations of RANTES, IFN-?
Regulation (concentrations) of RANTES associated with airway obstruction, sprains and strains and hantavirus infection
6) Confidence 0.06 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 1.61 Pain Relevance 0.04
ARA = American Rheumatism Association; bFGF = basic fibroblast growth factor; CCP = cyclic citrullinated peptide; CRP = C-reactive protein; DC = dendritic cell; EGF = epidermal growth factor; GM-CSF = granulocyte–macrophage colony-stimulating factor; IFN = interferon; IL = interleukin; MCP = monocyte chemoattractant protein; MIP = macrophage inflammatory protein; PsA = psoriatic arthritis; RA = rheumatoid arthritis; RANTES = regulated on activation, normal T expressed and secreted; ReA = reactive arthritis; RF = rheumatoid factor; Th = T-helper (cell); TNF = tumour necrosis factor.


Regulation (regulated) of RANTES in dendritic cell associated with seronegative spondarthritis, necrosis, inflammation, cancer, rheumatoid arthritis, rheumatism and arthritis
7) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.50 Pain Relevance 0.70
Since chemokines may be released into CSF from inflamed spinal nerve roots, we studied the concentrations of the chemokines MCP-1, MIP-1beta, MIP-3beta, IP-10, SDF-1alpha, RANTES, and SLC in the CSF by sandwich ELISA in patients over the course of GBS and CIDP, before and after immunomodulatory treatment.
Regulation (concentrations) of RANTES in spinal nerve associated with chemokine, chronic inflammatory demyelinating polyradiculoneuropathy and syndrome
8) Confidence 0.00 Published 2003 Journal J. Clin. Immunol. Section Abstract Doc Link 12959218 Disease Relevance 1.28 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox