INT112974

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 20
Disease Relevance 7.72
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
BAT 5
sensory neurons 2
skeletal muscle 2
liver 1
muscle 1
Ucp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 1 99.32 Very High Very High Very High
qutenza 32 97.26 Very High Very High Very High
dorsal root ganglion 9 84.68 Quite High
halothane 7 84.28 Quite High
Central nervous system 1 79.12 Quite High
cytokine 1 71.04 Quite High
Inflammation 2 48.88 Quite Low
anesthesia 11 25.00 Low Low
ketamine 18 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 173 100.00 Very High Very High Very High
Body Weight 71 97.24 Very High Very High Very High
Fever 1 94.08 High High
Hypoxia 68 84.72 Quite High
Ganglion Cysts 9 84.68 Quite High
Chronic Renal Failure 5 84.68 Quite High
Diabetes Mellitus 136 84.36 Quite High
Diabetes Complications 6 81.40 Quite High
Stress 44 80.96 Quite High
Sleep Disorders 5 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that the blunting of renal sensory neurons after kidney partial ablation may contribute to the lack of suppression of sympathetic efferent outflow towards BAT, modifying the glucose metabolism signaling pathway, UCP 1 expression and liver mitocondrial respiratory chain activity.
Gene_expression (expression) of UCP 1 in sensory neurons
1) Confidence 0.78 Published 2008 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 18593740 Disease Relevance 0.08 Pain Relevance 0
METHODS: To evaluate the influence of renal mass reduction, renal denervation and chronic deafferentation by capsaicin on thermoregulation, glucose metabolism, UCP1 expression and liver mitocondrial respiration, was used respectively, the blocking of heat dissipation by thermoneutral body water immersion, the oxygen consumption by Clark-type electrode, and western blot method.
Gene_expression (expression) of UCP1 in body
2) Confidence 0.78 Published 2008 Journal Nephrol. Dial. Transplant. Section Body Doc Link 18593740 Disease Relevance 0 Pain Relevance 0
Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats.
Gene_expression (expression) of UCP1 in adipose tissues associated with qutenza
3) Confidence 0.77 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.23 Pain Relevance 0.68
Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats.
Gene_expression (expression) of Uncoupling protein 1 in adipose tissues associated with qutenza
4) Confidence 0.77 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.23 Pain Relevance 0.69
The UCP1 expression is regulated by catecholamines, thyroid hormones and leptin and occurs, for example, during the exposure to cold [17], in the postnatal period, in febrile stages or during hibernation [18].
Gene_expression (expression) of UCP1 in thyroid associated with catecholamine and fever
5) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.45 Pain Relevance 0.09
Additionally, we demonstrated that exposure of bilateral renal denervated or of renal chronic capsaicin-treated rats to a similar experimental protocol results in a fast and high rise in rectal temperature response, and this is associated with a significant increase in the basal serine phosphorylation and protein levels of Akt and protein levels of UCP1.
Gene_expression (levels) of UCP1
6) Confidence 0.60 Published 2008 Journal Nephrol. Dial. Transplant. Section Body Doc Link 18593740 Disease Relevance 0 Pain Relevance 0
Additionally, we demonstrated that exposure of bilateral renal denervated or of renal chronic capsaicin-treated rats to a similar experimental protocol results in a fast and high rise in rectal temperature response, and this is associated with a significant increase in the basal serine phosphorylation and protein levels of Akt and protein levels of UCP1.
Gene_expression (levels) of UCP1
7) Confidence 0.60 Published 2008 Journal Nephrol. Dial. Transplant. Section Body Doc Link 18593740 Disease Relevance 0 Pain Relevance 0
These results indicate a critical role of capsaicin-sensitive sensory neurons in both heat and cool sensation and hence in basal thermal homeostasis, which is balanced by heat release and production including UCP1 thermogenesis, following sensation of the ambient temperature.
Gene_expression (production) of UCP1 in sensory neurons associated with qutenza
8) Confidence 0.60 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.19 Pain Relevance 0.62
activator, did not affect expression of UCP-1, -2, or UCP-3 in BAT (20).
Gene_expression (expression) of UCP associated with obesity
9) Confidence 0.52 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.58 Pain Relevance 0
There is strong evidence that increased fat metabolism is associated with increased expression of UCP-2 and UCP-3 (14, 15).
Gene_expression (expression) of UCP in fat
10) Confidence 0.52 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.74 Pain Relevance 0
activators have been suggested to induce the expression of UCP-2 in hepatocytes (16) and UCP-3 in adipose tissues (17, 18) and skeletal muscles (19).
Gene_expression (expression) of UCP in skeletal muscles
11) Confidence 0.52 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.61 Pain Relevance 0
Because UCP genes contain functional PPAR-responsive elements (24), they may be target genes for the PPAR activator (25).
Gene_expression (contain) of UCP
12) Confidence 0.45 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0 Pain Relevance 0
UCP-1, which is expressed exclusively in BAT, expression levels are reduced in several rodent models of obesity (12).
Gene_expression (expressed) of UCP in BAT associated with obesity
13) Confidence 0.40 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.82 Pain Relevance 0
UCP-1, which is expressed exclusively in BAT, expression levels are reduced in several rodent models of obesity (12).
Gene_expression (expression) of UCP in BAT associated with obesity
14) Confidence 0.40 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.82 Pain Relevance 0
In this study we observed that fenofibrate did not significantly increase the expression of UCP-2 mRNA and UCP-3 mRNA in skeletal muscle, but induced newly expressed UCP-3 mRNA in hepatic tissues.
Gene_expression (expression) of UCP in skeletal muscle
15) Confidence 0.40 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.08 Pain Relevance 0
The expression of UCP-2 and UPC-3 in liver and muscle
Gene_expression (expression) of UCP in liver
16) Confidence 0.40 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.23 Pain Relevance 0
Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue.
Gene_expression (levels) of UCP1 in adipose tissue associated with obesity
17) Confidence 0.37 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12959953 Disease Relevance 0.46 Pain Relevance 0.15
What is more important is that blockade of ┬ĽO2- radicals by three different approaches using either a small molecule uncoupler of mitochondrial oxidative phosphorylation (CCCP), overexpression of uncoupling protein-1 (UCP1) or overexpression of Mn-SOD, prevented changes in NF-?
Gene_expression (overexpression) of UCP1
18) Confidence 0.30 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.70 Pain Relevance 0.04
The expression of UCP-2 and UPC-3 in liver and muscle
Gene_expression (expression) of UCP in muscle
19) Confidence 0.14 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.23 Pain Relevance 0
We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects.
Gene_expression (expression) of uncoupling protein-1
20) Confidence 0.12 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242813 Disease Relevance 0.24 Pain Relevance 0.18

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