INT112978

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.56
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
skeletal muscle 4
fat 2
adipose tissue 2
Ucp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 7 84.60 Quite High
qutenza 4 79.08 Quite High
cytokine 2 71.04 Quite High
anesthesia 4 25.00 Low Low
Tetrahydrobiopterin 8 5.00 Very Low Very Low Very Low
diabetic neuropathy 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 47 98.92 Very High Very High Very High
Body Weight 22 97.80 Very High Very High Very High
Diabetes Complications 12 83.00 Quite High
Stress 84 80.96 Quite High
Diabetes Mellitus 197 78.72 Quite High
Hyperglycemia 16 74.60 Quite High
Weight Gain 12 34.76 Quite Low
Disorder Of Lipid Metabolism 21 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Myocardial Infarction 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activators have been suggested to induce the expression of UCP-2 in hepatocytes (16) and UCP-3 in adipose tissues (17, 18) and skeletal muscles (19).
Positive_regulation (induce) of Gene_expression (expression) of UCP in skeletal muscles
1) Confidence 0.46 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.62 Pain Relevance 0
There is strong evidence that increased fat metabolism is associated with increased expression of UCP-2 and UCP-3 (14, 15).
Positive_regulation (increased) of Gene_expression (expression) of UCP in fat
2) Confidence 0.33 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.74 Pain Relevance 0
In this study we observed that fenofibrate did not significantly increase the expression of UCP-2 mRNA and UCP-3 mRNA in skeletal muscle, but induced newly expressed UCP-3 mRNA in hepatic tissues.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of UCP in skeletal muscle
3) Confidence 0.31 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.08 Pain Relevance 0
Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue.
Positive_regulation (increased) of Gene_expression (levels) of UCP1 in adipose tissue associated with obesity
4) Confidence 0.28 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12959953 Disease Relevance 0.47 Pain Relevance 0.15
What is more important is that blockade of •O2- radicals by three different approaches using either a small molecule uncoupler of mitochondrial oxidative phosphorylation (CCCP), overexpression of uncoupling protein-1 (UCP1) or overexpression of Mn-SOD, prevented changes in NF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of UCP1
5) Confidence 0.23 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.71 Pain Relevance 0.04
What is more important is that blockade of •O2- radicals by three different approaches using either a small molecule uncoupler of mitochondrial oxidative phosphorylation (CCCP), overexpression of uncoupling protein-1 (UCP1) or overexpression of Mn-SOD, prevented changes in NF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of UCP1
6) Confidence 0.23 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.70 Pain Relevance 0.04
We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects.
Positive_regulation (induced) of Gene_expression (expression) of uncoupling protein-1
7) Confidence 0.11 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242813 Disease Relevance 0.24 Pain Relevance 0.18

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