INT11298

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 14
Disease Relevance 6.71
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
oral mucosa 1
Ido1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 207 99.82 Very High Very High Very High
antagonist 4 99.56 Very High Very High Very High
Analgesic 155 98.98 Very High Very High Very High
Pain 55 94.64 High High
withdrawal 252 94.32 High High
cINOD 3 90.32 High High
nociceptor 2 52.40 Quite High
Pain score 19 38.60 Quite Low
allodynia 1 35.28 Quite Low
agonist 8 35.20 Quite Low
Disease Link Frequency Relevance Heat
Overdose 612 100.00 Very High Very High Very High
Overactive Bladder 29 100.00 Very High Very High Very High
Bladder Disease 40 95.12 Very High Very High Very High
INFLAMMATION 4 90.08 High High
Pain 54 89.04 High High
Suicidal Behaviour 126 82.80 Quite High
Disorders Of Creatine Metabolism 1 81.44 Quite High
Poisoning 27 69.12 Quite High
Canker Sores 4 50.00 Quite Low
Hypersensitivity 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These hospitals accounted for 86.5% of all Registry-recorded IDO presentations in 2006-2008.
Gene_expression (presentations) of IDO associated with overdose
1) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.24 Pain Relevance 0.08
Data analysis was carried out relating to all IDO presentations, presentations involving any paracetamol-containing drug and presentations involving distalgesic.
Gene_expression (presentations) of IDO associated with paracetamol and overdose
2) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.29 Pain Relevance 0.38
The increased availability of the other prescription compound analgesics resulted in a significant increase in the rate of IDO presentations to hospital involving these drugs.
Gene_expression (presentations) of IDO associated with analgesic and overdose
3) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.63 Pain Relevance 0.50
However, the magnitude of the decrease in distalgesic-related IDO presentations was about five times greater than the magnitude of the increase in IDO presentations involving the other prescription compound analgesics.
Gene_expression (presentations) of IDO associated with analgesic and overdose
4) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.65 Pain Relevance 0.55
Sales of the drug to retail pharmacies decreased by 99% in 2006 whereas the rate of distalgesic-related IDO presentations was 72%, 84% and 94% lower in 2006, 2007 and 2008, respectively.
Gene_expression (presentations) of IDO associated with overdose
5) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.78 Pain Relevance 0.39
There was no trend evident in the rate of IDO presentations involving solpadeine.
Gene_expression (presentations) of IDO associated with overdose
6) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.74 Pain Relevance 0.42
This trend was also evident for IDO presentations involving a paracetamol-containing drug.
Gene_expression (presentations) of IDO associated with paracetamol and overdose
7) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.53 Pain Relevance 0.46
A similar pattern was observed when distalgesic was considered as a proportion of all paracetamol-related IDO presentations.
Gene_expression (presentations) of IDO associated with paracetamol and overdose
8) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.66 Pain Relevance 0.56
There was also evidence of a degree of substitution in respect of IDO presentations to hospital.
Gene_expression (presentations) of IDO associated with overdose
9) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.59 Pain Relevance 0.48
At these serum concentrations, IBU and INDO produced greater than 80% decrease in the urinary excretion of prostaglandin (PG) E2.
Gene_expression (produced) of INDO
10) Confidence 0.53 Published 1992 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1549620 Disease Relevance 0.23 Pain Relevance 0.23
However, the antagonist effects of l-NAME or INDO were more pronounced in the case of l-NAME plus INDO.
Gene_expression (pronounced) of INDO associated with antagonist
11) Confidence 0.27 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635640 Disease Relevance 0 Pain Relevance 0.05
However, the antagonist effects of l-NAME or INDO were more pronounced in the case of l-NAME plus INDO.
Gene_expression (pronounced) of INDO associated with antagonist
12) Confidence 0.27 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635640 Disease Relevance 0 Pain Relevance 0.05
CONCLUSIONS: These findings suggest that CD4(+)CD25(high) Treg cells are both functionally and quantitatively compromised in RAS and that decreased constitutive expression of IDO in oral mucosa in RAS may lead to the loss of local immune tolerance.


Gene_expression (expression) of IDO in oral mucosa
13) Confidence 0.10 Published 2008 Journal J. Oral Pathol. Med. Section Body Doc Link 18318707 Disease Relevance 0 Pain Relevance 0
IDO : Idiopathic detrusor overactivity
Gene_expression (overactivity) of IDO associated with overactive bladder
14) Confidence 0.06 Published 2006 Journal BMC Urol Section Body Doc Link PMC1766360 Disease Relevance 1.38 Pain Relevance 0.70

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