INT112986

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 17.61
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
brain 5
extracellular matrix 2
hippocampus 1
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 92 100.00 Very High Very High Very High
fluoxetine 92 99.98 Very High Very High Very High
antidepressant 16 99.76 Very High Very High Very High
cytokine 103 99.48 Very High Very High Very High
Hippocampus 59 99.12 Very High Very High Very High
ischemia 11 97.88 Very High Very High Very High
Neuritis 3 97.32 Very High Very High Very High
cva 12 93.68 High High
sSRI 384 92.84 High High
Norepinephrine uptake inhibitor 4 88.80 High High
Disease Link Frequency Relevance Heat
Injury 287 99.74 Very High Very High Very High
Stab Wounds 60 99.68 Very High Very High Very High
Aging 29 99.52 Very High Very High Very High
Brain Injury 139 99.26 Very High Very High Very High
Disease 530 98.72 Very High Very High Very High
Convulsion 4 98.48 Very High Very High Very High
Hypertrophy 15 98.10 Very High Very High Very High
Cerebral Malaria 26 98.04 Very High Very High Very High
Cognitive Disorder 252 98.00 Very High Very High Very High
Cv Unclassified Under Development 8 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, brain levels of S100B mRNA and protein increase with advancing age.
Positive_regulation (increase) of S100B in brain
1) Confidence 0.70 Published 2003 Journal Neuroreport Section Abstract Doc Link 12960766 Disease Relevance 0.26 Pain Relevance 0.57
The antidepressant fluoxetine increases hippocampal S100B content in young adult rats.
Positive_regulation (increases) of S100B associated with antidepressant and fluoxetine
2) Confidence 0.61 Published 2003 Journal Neuroreport Section Abstract Doc Link 12960766 Disease Relevance 0.27 Pain Relevance 0.55
Fluoxetine treatment of old mice further increased hippocampal S100B, suggesting that aging does not interfere with fluoxetine's action on hippocampal S100B.
Positive_regulation (increased) of S100B associated with aging and fluoxetine
3) Confidence 0.61 Published 2003 Journal Neuroreport Section Abstract Doc Link 12960766 Disease Relevance 0.33 Pain Relevance 0.61
S100B activation of RAGE upregulates IL-1?
Positive_regulation (activation) of S100B
4) Confidence 0.50 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.80 Pain Relevance 0.03
Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus.
Positive_regulation (increase) of S100B in hippocampus associated with aging, hippocampus and fluoxetine
5) Confidence 0.44 Published 2003 Journal Neuroreport Section Title Doc Link 12960766 Disease Relevance 0.28 Pain Relevance 0.59
Recent evidence indicates that high levels of S100 B in CSF increase the risk of repeated seizures in children with severe P. falciparum infection due to axonal injury [60].
Positive_regulation (levels) of S100 B associated with convulsion, injury and infection
6) Confidence 0.34 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 2.13 Pain Relevance 0.10
Elevated levels of S100B have been found in patients following brain trauma, ischemia/infarction, Alzheimer's disease, and Down's syndrome [42].
Positive_regulation (levels) of S100B in brain associated with syndrome, ischemia, disease, infarction and brain injury
7) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.93 Pain Relevance 0.08
S100B, along with S100A1 and S100A6, are the most abundant S100 proteins in the brain of several species including mice and rats.
Positive_regulation (abundant) of S100B in brain
8) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.88 Pain Relevance 0.08
1 and S100B (Fig. 5C, D), glial proteins, GFAP and NF-L (Fig. 6C, D), and enzyme, tTG (Fig. 7C, D), coincided with their protein levels, with significantly elevated levels of mRNA seen at 1 and 4 wpi.
Positive_regulation (elevated) of S100B
9) Confidence 0.28 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.84 Pain Relevance 0.12
However, there were no cognitive or mood or behavioral descriptions of the older mice with or without fluoxetine administration and therefore no clinical implications of the increased S100B.
Neg (no) Positive_regulation (increased) of S100B associated with cognitive disorder and fluoxetine
10) Confidence 0.24 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.98 Pain Relevance 0.87
Administration of fluoxetine to the young adult rat increases hippocampal levels of S100B (Haring et al 1993), but aging humans have increased levels of S100B mRNA expression (Sheng et al 1996), and excessive amounts of CNS S100B paradoxically promote apoptosis in mice prone to accelerated senescence (Griffin et al 1998).
Positive_regulation (increases) of S100B associated with aging, apoptosis and fluoxetine
11) Confidence 0.24 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.44 Pain Relevance 0.79
Fluoxetine further increased that abnormal level of S100B.
Positive_regulation (increased) of S100B associated with fluoxetine
12) Confidence 0.20 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.07 Pain Relevance 0.88
The older mice had higher levels of S100B.
Positive_regulation (levels) of S100B
13) Confidence 0.19 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.11 Pain Relevance 0.92
Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice

Background

Positive_regulation (enhanced) of S100B in Brain associated with brain injury
14) Confidence 0.14 Published 2008 Journal BMC Infect Dis Section Title Doc Link PMC2442079 Disease Relevance 1.07 Pain Relevance 0
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Positive_regulation (induction) of S-100B in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
15) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.98 Pain Relevance 0.18
In addition, the calcium regulatory protein S-100B was upregulated by the stab wound injury, but the levels of expression were not different between WT and IL-1R1-null mice.
Positive_regulation (upregulated) of protein S-100B associated with injury and stab wounds
16) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.79 Pain Relevance 0.19
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Positive_regulation (induction) of S-100B in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
17) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.91 Pain Relevance 0.18
However, the induction of chondroitin sulfate proteoglycans, tenascin, S-100B as well as glutamate transporter proteins, GLAST and GLT-1, and glutamine synthetase are independent of IL-1RI signaling.
Positive_regulation (induction) of S-100B associated with glutamate
18) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1533808 Disease Relevance 0.71 Pain Relevance 0.09
Axons are the most susceptible to ischemic or toxic damage in different brain areas, and axonal injury detected by elevated CSF levels of tau protein and S-100B (markers of axonal damage) were observed during cerebral malaria in Kenyan children [25].
Positive_regulation (elevated) of S-100B in brain associated with injury and cerebral malaria
19) Confidence 0.01 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.83 Pain Relevance 0.05

General Comments

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