INT112988

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) extracellular region (S100b) nucleus (S100b)
cytoplasm (S100b)
Anatomy Link Frequency
brain 2
S100b (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 23 97.90 Very High Very High Very High
antidepressant 4 96.56 Very High Very High Very High
cytokine 2 92.12 High High
sSRI 96 89.60 High High
Norepinephrine uptake inhibitor 1 85.56 High High
Hippocampus 14 78.80 Quite High
imagery 2 46.04 Quite Low
5HT 18 5.00 Very Low Very Low Very Low
Serotonin 14 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 99.74 Very High Very High Very High
Apoptosis 5 96.88 Very High Very High Very High
Disease 105 95.76 Very High Very High Very High
Neurodegenerative Disease 11 79.88 Quite High
Stress 3 71.76 Quite High
Cognitive Disorder 62 67.36 Quite High
Targeted Disruption 1 67.12 Quite High
Injury 1 65.24 Quite High
Alzheimer's Dementia 10 52.08 Quite High
Amyloid Plaque 5 51.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, brain levels of S100B mRNA and protein increase with advancing age.
Positive_regulation (increase) of Transcription (levels) of S100B in brain
1) Confidence 0.47 Published 2003 Journal Neuroreport Section Abstract Doc Link 12960766 Disease Relevance 0.26 Pain Relevance 0.57
Administration of fluoxetine to the young adult rat increases hippocampal levels of S100B (Haring et al 1993), but aging humans have increased levels of S100B mRNA expression (Sheng et al 1996), and excessive amounts of CNS S100B paradoxically promote apoptosis in mice prone to accelerated senescence (Griffin et al 1998).
Positive_regulation (increased) of Transcription (expression) of S100B associated with aging, apoptosis and fluoxetine
2) Confidence 0.19 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.35 Pain Relevance 0.79

General Comments

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