INT112989

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 25.40
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AIP) cytoplasm (AIP) signal transducer activity (AIP)
cytosol (AIP) signal transduction (AIP) nucleolus (AIP)
Anatomy Link Frequency
pancreas 2
bile duct 1
fibroblasts 1
duct 1
T-cell 1
AIP (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 533 100.00 Very High Very High Very High
Chronic pancreatitis 132 100.00 Very High Very High Very High
Bile 234 97.88 Very High Very High Very High
Inflammation 273 93.72 High High
imagery 78 89.52 High High
abdominal pain 13 87.28 High High
palliative 1 79.16 Quite High
Pain 26 73.92 Quite High
positron emission tomography 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 2206 100.00 Very High Very High Very High
Pancreatic Cancer 212 100.00 Very High Very High Very High
Retroperitoneal Fibrosis 195 100.00 Very High Very High Very High
Porphyria 8 100.00 Very High Very High Very High
Diabetes Mellitus 78 99.90 Very High Very High Very High
Obstructive Jaundice 104 99.64 Very High Very High Very High
Fibrosis 377 99.60 Very High Very High Very High
Disease 521 99.56 Very High Very High Very High
Exocrine Pancreatic Insufficiency 26 98.88 Very High Very High Very High
Pathologic Constriction 104 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all nine of the patients who were treated with steroids, both the retroperitoneal fibrosis and AIP were resolved.
Gene_expression (resolved) of AIP associated with fibrosis, retroperitoneal fibrosis and pancreatitis
1) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.13 Pain Relevance 0.31
For the diagnosis of AIP, either all of the criteria should be present or criterion 1 together with either criterion 2 or criterion 3.
Gene_expression (diagnosis) of AIP associated with pancreatitis
2) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 0.84 Pain Relevance 0.18
Many new clinical aspects of AIP have been clarified during the past 10 years, and AIP has become a distinct entity recognized worldwide.4–6
Gene_expression (aspects) of AIP associated with pancreatitis
3) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.59 Pain Relevance 0.17
AIP has been described by various names reflecting different aspects of the entity and each emphasizing the clinical, radiological, or histological findings: for example, chronic inflammatory sclerosis of the pancreas,1 duct-narrowing chronic pancreatitis (DNCP),2 lymphoplasmacytic sclerosing pancreatitis,22 nonalcoholic duct destructive chronic pancreatitis,23 and idiopathic tumefactive chronic pancreatitis.24

Prevalence

Gene_expression (described) of AIP in duct associated with inflammation, sclerosis, pancreatitis and chronic pancreatitis
4) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.87 Pain Relevance 0.47
In our 1- to 22-year follow-up study of AIP patients, the prognosis was almost always good, except in two patients who progressed to pancreatic insufficiency after resection.82 It has been reported that recurrent attacks of AIP result in pancreatic stone formation in some cases.38

Clinical subtype

Gene_expression (attacks) of AIP associated with exocrine pancreatic insufficiency and pancreatitis
5) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.71 Pain Relevance 0.23
In many cases, the diagnoses of diabetes mellitus and AIP are made simultaneously; some patients show exacerbation of preexisting diabetes mellitus with the onset of AIP.40 Tanaka et al.41,42 reported that diabetes mellitus with AIP was caused by T-cell-mediated mechanisms primarily involving islet ?
Gene_expression (made) of AIP in T-cell associated with diabetes mellitus and pancreatitis
6) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.93 Pain Relevance 0.03
Localized AIP may extend progressively to the whole pancreas.18,19 The current concept of AIP, including associated extrapancreatic lesions, suggests that AIP may be a systemic disease.7,8,20,21
Gene_expression (extend) of AIP in pancreas associated with pancreatitis and disease
7) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.92 Pain Relevance 0.37
In all nine of the patients who were treated with steroids, both the retroperitoneal fibrosis and AIP were resolved.
Gene_expression (fibrosis) of AIP associated with fibrosis, retroperitoneal fibrosis and pancreatitis
8) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.13 Pain Relevance 0.31
The indications for steroid therapy in AIP include obstructive jaundice due to stenosis of the bile duct or the presence of other associated systemic diseases, such as retroperitoneal fibrosis.79 Steroid therapy is also effective for sclerosing cholangitis that relapses after surgery.80,81
Gene_expression (therapy) of AIP in bile duct associated with bile, pancreatitis, sclerosing cholangitis, disease, recurrence, obstructive jaundice, fibrosis, pathologic constriction and retroperitoneal fibrosis
9) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.48 Pain Relevance 0.13
Extrapancreatic lesions of AIP
Gene_expression (lesions) of AIP associated with pancreatitis
10) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.03 Pain Relevance 0.21
Other reported prevalence rates of AIP among chronic pancreatitis cases are 4.6% (21/451) in Japan,27 5.4% (17/315) in Korea,16 and 6.0% (23/383) in Italy.27 In North America, about 2.5% of pancreatoduodenectomies are performed for AIP because of a mistaken diagnosis of pancreatic cancer,28 and AIP cases represent between 21%29 and 23%28 of pancreatoduodenectomies performed for benign conditions.
Gene_expression (represent) of AIP associated with pancreatic cancer, pancreatitis and chronic pancreatitis
11) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.94 Pain Relevance 0.57
Localized AIP may extend progressively to the whole pancreas.18,19 The current concept of AIP, including associated extrapancreatic lesions, suggests that AIP may be a systemic disease.7,8,20,21
Gene_expression (extend) of AIP in pancreas associated with pancreatitis and disease
12) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.97 Pain Relevance 0.38
Other reported prevalence rates of AIP among chronic pancreatitis cases are 4.6% (21/451) in Japan,27 5.4% (17/315) in Korea,16 and 6.0% (23/383) in Italy.27 In North America, about 2.5% of pancreatoduodenectomies are performed for AIP because of a mistaken diagnosis of pancreatic cancer,28 and AIP cases represent between 21%29 and 23%28 of pancreatoduodenectomies performed for benign conditions.
Gene_expression (represent) of AIP associated with pancreatic cancer, pancreatitis and chronic pancreatitis
13) Confidence 0.56 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.33 Pain Relevance 0.64
To confirm this, we tried to examine a utility of IgG4 by measuring serum IgG4 levels of patients with healthy human, AIP, chronic pancreatitis, pancreatic cancer and autoimmune disease with nephelometric immunoassay (NIA).
Gene_expression (levels) of AIP associated with autoimmune disease, pancreatic cancer, pancreatitis and chronic pancreatitis
14) Confidence 0.40 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20496768 Disease Relevance 0.89 Pain Relevance 0.15
Human AIP fibroblasts synthesized 21% and mouse PBGD deficient fibroblasts only 11% of the PP amount synthesized in respective control cells.
Gene_expression (synthesized) of AIP in fibroblasts associated with porphyria
15) Confidence 0.14 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12962144 Disease Relevance 0.63 Pain Relevance 0.08

General Comments

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