INT113

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Context Info
Confidence 0.49
First Reported 1976
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 6.76
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (MBD2) nucleus (MBD2) DNA binding (MBD2)
cytoplasm (MBD2)
Anatomy Link Frequency
liver 10
poly 1
brain 1
lung 1
MBD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 20 100.00 Very High Very High Very High
cocaine 12 100.00 Very High Very High Very High
algil 4 99.98 Very High Very High Very High
Paracetamol 32 99.44 Very High Very High Very High
methadone 18 96.92 Very High Very High Very High
tolerance 8 88.48 High High
alcohol 9 86.76 High High
qutenza 1 84.84 Quite High
Serotonin 13 81.84 Quite High
addiction 32 81.52 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 684 99.84 Very High Very High Very High
Cataract 6 95.32 Very High Very High Very High
Paralysis 6 95.12 Very High Very High Very High
Weight Gain 7 91.04 High High
Suicidal Behaviour 4 89.68 High High
Nephrotoxicity 1 87.80 High High
Hepatotoxicity 15 87.04 High High
Colon Cancer 6 83.48 Quite High
Toxicity 11 80.84 Quite High
Injury 5 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was interesting to note that the induction of N-demethylases by repeated methaqualone intake was differential in nature since diphenhydramine and morphine N-demethylases were induced about twofold whereas pethidine N-demethylase was enhanced about fourfold.
Positive_regulation (enhanced) of N-demethylase associated with algil and morphine
1) Confidence 0.49 Published 1980 Journal Pharmacology Section Abstract Doc Link 7384198 Disease Relevance 0 Pain Relevance 0.67
A higher dose of cocaine, 60 mg/kg, elevated the SGOT activity and reduced cocaine N-demethylase activity and 4-nitrophenol GT activity in both SHR and WKY rats.
Positive_regulation (elevated) of N-demethylase associated with cocaine
2) Confidence 0.21 Published 1987 Journal Alcohol Drug Res Section Abstract Doc Link 3113443 Disease Relevance 0.34 Pain Relevance 0.54
Haloperidol, when given to rats, did not change the microsomal N-demethylase activity in vitro; however, when introduced into incubation mixture, it inhibited the rate of ethylmorphine dealkylation.
Neg (not) Positive_regulation (change) of N-demethylase
3) Confidence 0.11 Published 1986 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 3748892 Disease Relevance 0 Pain Relevance 0.43
A 2.0 mg per kg oral dose of 1-alpha-acetylmethadol (LAAM) administered daily to female rats prior to mating and throughout pregnancy increased ethylmorphine N-demethylase activity in liver microsomes of the dams measured 24 h after parturition.
Positive_regulation (increased) of N-demethylase in liver
4) Confidence 0.09 Published 1983 Journal Life Sci. Section Abstract Doc Link 6684201 Disease Relevance 0.24 Pain Relevance 0.24
Glutathione-S-transferase activity was not affected by any treatment combinations, and p-nitroanisole O-demethylase activity and relative liver weights were not increased because of chronic ethanol ingestion.
Neg (not) Positive_regulation (increased) of O-demethylase in liver
5) Confidence 0.09 Published 1984 Journal Drug Nutr Interact Section Abstract Doc Link 6510240 Disease Relevance 0.23 Pain Relevance 0.47
However, subacute treatment of mice with methadone HCl (30 mg/kg, po, twice daily for 3 days) resulted in increases in liver weight, microsomal protein, and cytochrome P-450 content in consonant with the increased activities of four hepatic drug-metabolizing enzymes: aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole, O-demethylase, and benzphetamine N-demethylase.
Positive_regulation (increased) of N-demethylase in liver associated with methadone
6) Confidence 0.07 Published 1987 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3797427 Disease Relevance 0.16 Pain Relevance 0.47
However, subacute treatment of mice with methadone HCl (30 mg/kg, po, twice daily for 3 days) resulted in increases in liver weight, microsomal protein, and cytochrome P-450 content in consonant with the increased activities of four hepatic drug-metabolizing enzymes: aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole, O-demethylase, and benzphetamine N-demethylase.
Positive_regulation (increased) of O-demethylase in liver associated with methadone
7) Confidence 0.07 Published 1987 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3797427 Disease Relevance 0.16 Pain Relevance 0.48
However, subacute treatment of mice with methadone HCl (30 mg/kg, po, twice daily for 3 days) resulted in increases in liver weight, microsomal protein, and cytochrome P-450 content in consonant with the increased activities of four hepatic drug-metabolizing enzymes: aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole, O-demethylase, and benzphetamine N-demethylase.
Positive_regulation (increased) of N-demethylase in liver associated with methadone
8) Confidence 0.07 Published 1987 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3797427 Disease Relevance 0.17 Pain Relevance 0.48
The nucleic acid demethylase activity, possibly due to hyperactive poly(ADP-ribose) polymerases [46], is increased by tobacco smoke (Fig. 4C) and generates aldehydes [24], [47] (Fig. 5) which are able to further cyclize bioamines to generate ?
Positive_regulation (increased) of demethylase in poly associated with nicotine addiction
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.06 Pain Relevance 0.11
Demethylase activity was increased by 12.3±0.4 and 9.6±0.5% for harman and norharman (100 nM), respectively (n?
Positive_regulation (increased) of Demethylase
10) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.84 Pain Relevance 0
NS due to cigarette smoke-induced increase of nucleic acid demethylase activity.


Positive_regulation (increase) of demethylase associated with nicotine addiction
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775922 Disease Relevance 1.12 Pain Relevance 0.10
Moreover, the in vitro nucleic acid demethylase activity of mouse lung nuclear extracts was increased by harman and norharman, two known inhibitors of MAO present in tobacco smoke [24], [25].
Positive_regulation (increased) of demethylase in lung associated with nicotine addiction
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.82 Pain Relevance 0
The activities of O- and N-demethylase were first observed in the liver of 3- and 7-day-old rats, respectively, and increased to the adult level at 35 days of age.
Positive_regulation (increased) of N-demethylase in liver
13) Confidence 0.03 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6767021 Disease Relevance 0 Pain Relevance 0.09
Induction of hepatic propoxyphene N-demethylase and aniline hydroxylase activities resulted following repeated oral administration of 25, 50 and 100 mg d-propoxyphene hydrochloride per kg daily in the mouse over a six-day period.
Positive_regulation (Induction) of N-demethylase
14) Confidence 0.03 Published 1980 Journal Drug Alcohol Depend Section Abstract Doc Link 7353473 Disease Relevance 0.07 Pain Relevance 0.10
Furthermore, M73101 increased Vmax for both aniline hydroxylase and AM demethylase, whereas it increased Km only for aniline hydroxylase.
Positive_regulation (increased) of AM demethylase
15) Confidence 0.02 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 120300 Disease Relevance 0.14 Pain Relevance 0.09
The exact mechanism is not yet known, but it seems that VPA does not directly enhance the enzymatic activity of DNA demethylase.
Neg (not) Positive_regulation (enhance) of DNA demethylase
16) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.05 Pain Relevance 0
Moreover, microsomal induction by LAAM resulted in significant elevations of aminopyrine N-demethylase and aniline hydroxylase activities.
Positive_regulation (elevations) of N-demethylase
17) Confidence 0.02 Published 1978 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 663393 Disease Relevance 0 Pain Relevance 0.09
Acenaphthylene treatment of young DBA2 mice resulted in a 2-fold increase in cytochrome P450 1A2-dependent methoxyresorufin O-demethylase activity in the liver.
Positive_regulation (increase) of O-demethylase in liver
18) Confidence 0.01 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977129 Disease Relevance 0.38 Pain Relevance 0.43
This effect did not occur in vitro and did not require N-demethylase activity in the whole animal.
Neg (not) Positive_regulation (require) of N-demethylase
19) Confidence 0.01 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2891359 Disease Relevance 0.07 Pain Relevance 0.13
NDMA N-demethylase activity showed a two-fold induction at 24 and 48 weeks of ethanol treatment, compared with corresponding pair-fed control groups.
Positive_regulation (induction) of N-demethylase
20) Confidence 0.01 Published 1992 Journal Alcohol Alcohol. Section Abstract Doc Link 1524605 Disease Relevance 0.06 Pain Relevance 0.15

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