INT11300

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 10.18
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
hypothalamus 6
plasma 6
neuronal 2
neurons 2
pituitary 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 99.98 Very High Very High Very High
halothane 8 99.76 Very High Very High Very High
depression 112 97.84 Very High Very High Very High
cytokine 195 96.84 Very High Very High Very High
Eae 25 91.32 High High
Inflammation 45 90.12 High High
Neuropeptide 143 89.60 High High
Morphine 1 83.64 Quite High
Pain 16 82.64 Quite High
antagonist 33 73.32 Quite High
Disease Link Frequency Relevance Heat
Hyponatremia 75 99.96 Very High Very High Very High
Pre-eclampsia 92 99.86 Very High Very High Very High
Small Cell Lung Cancer 60 99.68 Very High Very High Very High
Syndrome 17 99.44 Very High Very High Very High
Stress 520 99.16 Very High Very High Very High
Pituitary Acth Hypersecretion 15 98.52 Very High Very High Very High
Meningitis 15 98.48 Very High Very High Very High
Anxiety Disorder 404 97.92 Very High Very High Very High
Viral Meningitis 15 97.92 Very High Very High Very High
Depression 114 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, differences in Avp expression were not accompanied by changes in V1a and V1b receptors that could confound the analysis of the behavioral involvement of AVP in these lines.
Positive_regulation (differences) of Gene_expression (expression) of Avp
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.66 Pain Relevance 0.07
Together with human studies [23], [60], they do not only ensure the construct validity of the HAB/LAB model, but additionally provide a strong impetus for Avp expression as a potential biomarker and therapeutic target in psychopathology.



Positive_regulation (impetus) of Gene_expression (expression) of Avp
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.52 Pain Relevance 0.08
Next we investigated whether differences in AVP expression originate from differences in the sequence of HAB and LAB alleles that could underpin differences in the recruitment of proteins driving transcription.
Spec (whether) Positive_regulation (differences) of Gene_expression (expression) of AVP
3) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.29 Pain Relevance 0.08
In this study, we identified polymorphisms in the Avp gene underlying a decreased expression of Avp mRNA in the hypothalamus of LAB animals under basal conditions compared to HAB, NAB and F1 mice, irrespective of gender.
Positive_regulation (underlying) of Gene_expression (expression) of Avp mRNA in hypothalamus associated with anxiety disorder
4) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.50 Pain Relevance 0.07
Chronic stress from repeated (daily) exposure to an acute stressor leading to ACTH hyperresponsiveness to a single, novel stressor episode may also involve an increase in PVN Avp (Ma et al. 1999) and pituitary Avpr1b expression, and pituitary ACTH hyperresponsiveness (Aguilera 1994).
Positive_regulation (increase) of Gene_expression (expression) of Avp in pituitary associated with stress
5) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.72 Pain Relevance 0.08
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Positive_regulation (response) of Gene_expression (production) of AVP associated with pre-eclampsia
6) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.10
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Positive_regulation (increased) of Gene_expression (production) of AVP associated with pre-eclampsia
7) Confidence 0.28 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.10
However, the splice variant of REST/NRSF, produced in several kinds of SCLC cells, interferes with the normal silencing function of wild-type REST/NRSF, facilitating the ectopic expression of the vasopressin gene in the heterologous cells (Coulson et al. 1999b).
Positive_regulation (facilitating) of Gene_expression (expression) of vasopressin gene associated with small cell lung cancer
8) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.10 Pain Relevance 0
USF1/USF2 is not a determinant which facilitates the vasopressin gene expression in the SCLC cells in particular, and not other non-neuronal cells, because these transcription factors are ubiquitously expressed.
Positive_regulation (facilitates) of Gene_expression (expression) of vasopressin gene in neuronal associated with small cell lung cancer
9) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.47 Pain Relevance 0
Several investigators have shown that osmotic stress induces the elongation of the poly (A) tail of vasopressin mRNA, resulting in the mRNA stability which promotes the vasopressin production (Carrazana, et al. 1988; Carter and Murphy, 1991).
Positive_regulation (promotes) of Gene_expression (production) of vasopressin in Murphy associated with stress
10) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.29 Pain Relevance 0
Almost all CRH-positive neurons do not express vasopressin in the basal condition; however, a number of these neurons start to express vasopressin after receiving the stress, resulting in the increase of the ACTH secretion via the corticotroph V1b receptor (V1bR), as is the case with CRH.
Positive_regulation (start) of Gene_expression (express) of vasopressin in corticotroph associated with stress
11) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.17 Pain Relevance 0
Upstream stimulatory factor 1 (USF1) and USF2 contribute to the ectopic vasopressin gene expression in the SCLC cells, by the binding of the E-box element in the vasopressin gene promoter region (Coulson et al. 1999a).
Positive_regulation (ectopic) of Gene_expression (expression) of vasopressin gene associated with small cell lung cancer
12) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.52 Pain Relevance 0
There is much evidence that the cAMP/PKA activation leads to the immediate induction of the vasopressin gene expression.
Positive_regulation (induction) of Gene_expression (expression) of vasopressin gene
13) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.32 Pain Relevance 0.11
Many previous studies have shown that the Fos/Jun family proteins are rapidly expressed in the vasopressinergic neurons in response to a variety of extracellular stimuli, synchronizing with the activation of vasopressin gene expression.
Positive_regulation (activation) of Gene_expression (expression) of vasopressin gene in neurons
14) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.31 Pain Relevance 0
For example, clinically, excessive production of vasopressin is known to cause SIADH, whereas excessive CRH causes Cushing disease, depression, and anorexia nervosa.
Positive_regulation (cause) of Gene_expression (production) of vasopressin associated with hyponatremia, depression, pituitary acth hypersecretion and eating disorder
15) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.52 Pain Relevance 0.13
In addition, the cAMP activator elevates the vasopressin gene expression in fetal hypothalamic culture (Hu et al. 1993) and dissociated hypothalamic primary culture (Wei et al. 2002).
Positive_regulation (elevates) of Gene_expression (expression) of vasopressin gene
16) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.27 Pain Relevance 0.07
The vasopressin and CRH gene expression is activated by numerous physiological stimuli, as described above.
Positive_regulation (activated) of Gene_expression (expression) of vasopressin
17) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.50 Pain Relevance 0.17
It is concluded that halothane anesthesia increases the plasma levels of AVP and ANG II in sheep, and that the maintenance of the arterial pressure is dependent on the concurrent vasopressor effects of the two hormones in this situation.
Positive_regulation (increases) of Gene_expression (levels) of AVP in plasma associated with anesthesia and halothane
18) Confidence 0.07 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1549932 Disease Relevance 0 Pain Relevance 0.52
The halothane anesthesia effectively increased the plasma levels of AVP and ANG II, and plasma renin activity without any relation to changes in MSAP.
Positive_regulation (increased) of Gene_expression (levels) of AVP in plasma associated with anesthesia and halothane
19) Confidence 0.07 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1549932 Disease Relevance 0 Pain Relevance 0.54
It is well-known that an excessive production of vasopressin induces the “syndrome of inappropriate secretion of antidiuretic hormone (SIADH),” which is characterized by hyponatoremia with excessive sodium excretion from the kidney (Bartter and Schwartz, 1967; Robertson, 2006; Ellison and Berl, 2007).
Positive_regulation (excessive) of Gene_expression (production) of vasopressin in kidney associated with hyponatremia and syndrome
20) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.72 Pain Relevance 0.19

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