INT113007

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.28
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
neurons 2
granule cell 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 56 100.00 Very High Very High Very High
Kappa opioid receptor 50 99.96 Very High Very High Very High
Serotonin 3 99.84 Very High Very High Very High
Dorsal horn neuron 9 97.52 Very High Very High Very High
gABA 9 96.16 Very High Very High Very High
Enkephalin 13 95.32 Very High Very High Very High
amygdala 46 94.60 High High
Endogenous opioid 4 92.48 High High
Raphe 3 91.80 High High
Opioid 6 89.76 High High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 4 99.98 Very High Very High Very High
Neurodegenerative Disease 5 99.86 Very High Very High Very High
Generalized Anxiety Disorder 12 97.52 Very High Very High Very High
Targeted Disruption 18 95.76 Very High Very High Very High
Stress 45 91.00 High High
Anxiety Disorder 46 75.00 Quite High
Cv Unclassified Under Development 2 75.00 Quite High
Mental Disorders 1 62.20 Quite High
Depression 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to a transient increase in neurogenesis, MCAO caused a transient up-regulation of preprodynorphin and preproenkephalin mRNA expression in the granule cell layer.
Positive_regulation (caused) of Positive_regulation (up-regulation) of preprodynorphin in granule cell associated with middle cerebral artery infarction and neurodegenerative disease
1) Confidence 0.49 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18331339 Disease Relevance 1.25 Pain Relevance 0.49
Using pharmacological and genetic approaches, we found that the anxiogenic-like effects of Corticotropin Releasing Factor (CRF) were triggered by CRF1-R activation of the dynorphin/kappa opioid receptor (KOR) system.
Positive_regulation (triggered) of Positive_regulation (activation) of dynorphin associated with dynorphin and kappa opioid receptor
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.71
RESULTS: Nicotine free base, 1 mg/kg, sc, induced a biphasic, protracted increase of striatal Dyn, an initial rise by 1 h, which declined to control levels by 2 h, and a subsequent increase, between 6 and 12 h, lasting over 24 h.
Positive_regulation (induced) of Positive_regulation (increase) of Dyn
3) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18807250 Disease Relevance 0 Pain Relevance 0
The glutamate NMDA receptor antagonist MK-801 reversed the nicotine-induced increase of Dyn, while the AMPA antagonist NBQX had a marginal effect.
Positive_regulation (induced) of Positive_regulation (increase) of Dyn
4) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18807250 Disease Relevance 0 Pain Relevance 0
Effects of c-fos antisense oligodeoxynucleotide (ASO) on serotonin (5-HT)-induced upregulation of preprodynorphin (ppDyn), preproenkephalin (ppEnk), and glutamic acid decarboxylase (GAD), a special chemical marker for gamma-aminobutyric acid (GABA) neurons, mRNAs in cultured spinal dorsal horn neurons were investigated in order to extend our understanding of expressions of opioid peptides and GABA in spinal cord regulated by the descending serotonergic efferents.
Positive_regulation (induced) of Positive_regulation (upregulation) of ppDyn in neurons associated with gaba, generalized anxiety disorder, opioid, dorsal horn neuron, serotonin and spinal cord
5) Confidence 0.01 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12963037 Disease Relevance 0.16 Pain Relevance 0.36
The immediate early oncogene c-fos might be involved in the 5-HT-induced increase in ppDyn and ppEnk expression.
Positive_regulation (5-HT-induced) of Positive_regulation (increase) of ppDyn
6) Confidence 0.00 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12963037 Disease Relevance 0.23 Pain Relevance 0.55
Moreover, c-fos ASO pretreatment significantly decreased the 5-HT-induced upregulation of ppDyn and ppEnk mRNAs, but failed to affect the expression level of GAD mRNA.
Positive_regulation (5-HT-induced) of Positive_regulation (upregulation) of ppDyn associated with generalized anxiety disorder
7) Confidence 0.00 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12963037 Disease Relevance 0.26 Pain Relevance 0.57

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