INT113021

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.94
Pain Relevance 4.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ADAM18)
Anatomy Link Frequency
tubule 1
ADAM18 (Homo sapiens)
ADAM18 - L858F (4)
Pain Link Frequency Relevance Heat
Nav1.7 392 100.00 Very High Very High Very High
Pain 46 94.24 High High
addiction 24 89.16 High High
sodium channel 40 82.00 Quite High
burning pain 8 71.12 Quite High
chronic pain syndrome 8 67.60 Quite High
dorsal root ganglion 40 66.60 Quite High
IPN 4 61.88 Quite High
neuralgia 2 10.00 Low Low
nav1.8 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythermalgia 108 100.00 Very High Very High Very High
Pain 44 94.24 High High
Disease 8 88.40 High High
Ganglion Cysts 48 86.12 High High
Nociception 8 84.52 Quite High
Neuropathic Pain 1 79.52 Quite High
Pressure And Volume Under Development 1 78.36 Quite High
Non-diabetic Peripheral Neuropathy 1 76.28 Quite High
Increased Venous Pressure Under Development 8 72.60 Quite High
Complex Regional Pain Syndromes 8 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double staining confocal microscope studies using anti-human protein-gene-product 9.5, anti-tubule, anti-neurofilament, and anti-synaptophysin antibodies were performed to assess specific accumulation within swellings.
Gene_expression (using) of protein-gene-product 9.5 in tubule
1) Confidence 0.37 Published 2003 Journal Neurology Section Body Doc Link 12963753 Disease Relevance 0.23 Pain Relevance 0
Whole-cell voltage-clamp measurements on wild type or L858F channels expressed in HEK293 cells revealed that cooling decreases current density, slows deactivation and increases ramp currents for both mutant and wild type channels.
Gene_expression (expressed) of L858F (L858F)
2) Confidence 0.01 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1781932 Disease Relevance 0.93 Pain Relevance 0.77
Whole-cell pa</span>tch-clamp recordings of sodium currents from HEK293 cells stably expressing WT or the IEM mutant Nav1.7 channel (L858F) were carried out at three different temperatures: 16°C, 25°C and 35°C.
Gene_expression (expressing) of L858F (L858F) associated with erythermalgia and nav1.7
3) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 1.03 Pain Relevance 1.47
As shown previously [7] L858F produces larger ramp currents than WT channels.
Gene_expression (produces) of L858F (L858F) associated with nav1.7
4) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 0 Pain Relevance 0.92
Both WT and L858F mutant channels produced fast activating and inactivating currents (Figure 1A).
Gene_expression (produced) of L858F (L858F) associated with nav1.7
5) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 0.75 Pain Relevance 1.32

General Comments

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