INT113029

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.97
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Anatomy Link Frequency
output neurons 1
muscle 1
leg 1
foot 1
Myo5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
Kappa opioid receptor 4 100.00 Very High Very High Very High
bradykinin 4 100.00 Very High Very High Very High
b2 receptor 1 100.00 Very High Very High Very High
Pain 9 99.96 Very High Very High Very High
mu opioid receptor 5 99.96 Very High Very High Very High
agonist 3 99.72 Very High Very High Very High
Inflammation 5 99.20 Very High Very High Very High
Perioperative pain 1 86.80 High High
Disease Link Frequency Relevance Heat
Pain 7 99.96 Very High Very High Very High
INFLAMMATION 5 99.20 Very High Very High Very High
Nociception 3 97.44 Very High Very High Very High
Osteoporosis 33 94.84 High High
Post Operative Pain 1 86.80 High High
Hypercalcemia 4 53.44 Quite High
Fracture Healing 13 45.52 Quite Low
Parkinson's Disease 1 42.68 Quite Low
Tics 1 28.12 Quite Low
Rheumatoid Arthritis 1 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The masseter-muscle spindle is regarded as being highly adaptable to increases in the occlusal vertical dimension (iOVD), it is hypothesized that spindle function would adapt to a decrease in occlusal vertical dimension (dOVD) as well.
Negative_regulation (decrease) of dOVD in muscle
1) Confidence 0.48 Published 2008 Journal Kokubyo Gakkai Zasshi Section Abstract Doc Link 18421946 Disease Relevance 0 Pain Relevance 0.05
After OVX, the magnitude of multi-unit responses to brushing the perineum, hip and tail, but not the foot and leg, were significantly reduced relative to shamOVX-D.
Negative_regulation (reduced) of shamOVX-D in leg
2) Confidence 0.42 Published 2003 Journal Brain Res. Section Abstract Doc Link 12965232 Disease Relevance 0 Pain Relevance 0
We conclude that UFP-512, depending on dose, improves or worsens motor activity in hemiparkinsonian rats by acting differentially as a DOP receptor agonist in SNr and a DOP receptor antagonist in GP, ultimately decreasing or increasing the activity of nigro-thalamic GABAergc output neurons, respectively.
Negative_regulation (antagonist) of DOP receptor in output neurons associated with antagonist and agonist
3) Confidence 0.35 Published 2009 Journal Neuroscience Section Abstract Doc Link 19729051 Disease Relevance 0 Pain Relevance 0.66
After OVX, the magnitude of multi-unit responses to brushing the perineum, hip and tail, but not the foot and leg, were significantly reduced relative to shamOVX-D.
Negative_regulation (reduced) of shamOVX-D in foot
4) Confidence 0.14 Published 2003 Journal Brain Res. Section Abstract Doc Link 12965232 Disease Relevance 0 Pain Relevance 0
Since these isoforms were initially identified in mice, the present study compared the effects of general and selective opioid receptor antagonists on deprivation-induced feeding in rats and mice and antisense probes directed against exons of the MOP, DOP, KOP, and NOP genes on deprivation-induced feeding in the mouse.
Negative_regulation (deprivation) of DOP associated with antagonist, kappa opioid receptor, mu opioid receptor and opioid receptor
5) Confidence 0.06 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15333676 Disease Relevance 0 Pain Relevance 1.15
Both des-Arg(8), Leu(8)-bradykinin (dALBK) and HOE-140, the prototypic bradykinin B1 and B2 receptor antagonists, respectively, have been shown to reduce pain behaviors and inflammation in animal models of persistent nociception.
Negative_regulation (reduce) of dALBK associated with nociception, pain, inflammation, antagonist, b2 receptor and bradykinin
6) Confidence 0.02 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385370 Disease Relevance 0.74 Pain Relevance 1.05
Among the differently regulated genes, the genes for IL-17 receptor A and FGF23 were up- and downregulated in OVX-D after 3 weeks.
Negative_regulation (downregulated) of OVX-D
7) Confidence 0.01 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.23 Pain Relevance 0.03

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