INT11303

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 116
Total Number 121
Disease Relevance 39.23
Pain Relevance 23.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
neurons 11
uterine 5
plasma 4
hypothalamus 4
paraventricular hypothalamic nucleus 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 269 100.00 Very High Very High Very High
antagonist 212 100.00 Very High Very High Very High
Kappa opioid receptor 160 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
analgesia 57 99.96 Very High Very High Very High
Dynorphin 21 99.90 Very High Very High Very High
depression 714 99.80 Very High Very High Very High
amygdala 375 99.68 Very High Very High Very High
Peripheral nervous system 33 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 913 100.00 Very High Very High Very High
Ganglion Cysts 303 100.00 Very High Very High Very High
Ebola Virus Infection 249 100.00 Very High Very High Very High
Depression 740 99.80 Very High Very High Very High
Neuroblastoma 86 99.78 Very High Very High Very High
Small Cell Lung Cancer 168 99.68 Very High Very High Very High
Small Cell Lung Carcinoma 42 99.48 Very High Very High Very High
Syndrome 52 99.44 Very High Very High Very High
Adrenal Insufficiency 84 99.36 Very High Very High Very High
Pre-eclampsia 230 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of an allele-dependent effect, heterozygous F1 mice revealed intermediate levels of Avp mRNA expression in the SON in comparison to LABs and HABs (p<0.1 F1 vs.
Gene_expression (expression) of Avp mRNA
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.27 Pain Relevance 0.03
Similarly, qPCR analysis showed a reduced Avp expression in the PVN (Fig. 1E) and SON (Fig. 2B) of both male and female LABs compared to HAB or NAB animals (PVN of male mice: p<0.05 vs.
Gene_expression (expression) of Avp associated with anxiety disorder
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.67 Pain Relevance 0.07
The application of similar breeding strategies in two different species (Rattus norvegicus and Mus musculus) resulted in similar findings concerning the identification of polymorphisms in and around the Avp gene and both the expression and release patterns of AVP.
Gene_expression (expression) of Avp
3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.72 Pain Relevance 0.08
Confirming microarray data, ISH revealed a decreased expression of Avp in both the PVN (Fig. 1D) and SON (Fig. 2A) in male LAB compared to both HAB and NAB mice (PVN: p<0.01 vs.
Gene_expression (expression) of Avp associated with anxiety disorder
4) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.75 Pain Relevance 0.08
Next we investigated whether differences in AVP expression originate from differences in the sequence of HAB and LAB alleles that could underpin differences in the recruitment of proteins driving transcription.
Gene_expression (expression) of AVP
5) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.29 Pain Relevance 0.08
Importantly, differences in Avp expression were not accompanied by changes in V1a and V1b receptors that could confound the analysis of the behavioral involvement of AVP in these lines.
Gene_expression (expression) of Avp
6) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.66 Pain Relevance 0.07
In contrast to strictly intermediate F1, NAB mice displayed in about 70% of all animals a HAB-like Avp expression and depression-like behavior in the tail-suspension test (Fig. 1B, D, E and [24]), which has also been demonstrated recently in an unselected CD1 population [59], thus further emphasizing the functional implications of centrally released AVP.
Gene_expression (expression) of Avp in tail associated with depression and anxiety disorder
7) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.83 Pain Relevance 0.08
As LAB mice exhibit a deficit not only in AVP precursor processing and neuropeptide release from both dendrites and axon terminals [25], but also in Avp expression, additive effects at multiple levels are likely to produce a more or less “global” deficit in bioactive AVP.
Gene_expression (expression) of Avp in dendrites associated with neuropeptide release
8) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.92 Pain Relevance 0.13
To obtain evidence for a functional role of these polymorphisms in contributing to different levels of AVP expression in male and female LAB vs.
Gene_expression (expression) of AVP
9) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.16 Pain Relevance 0
Together with human studies [23], [60], they do not only ensure the construct validity of the HAB/LAB model, but additionally provide a strong impetus for Avp expression as a potential biomarker and therapeutic target in psychopathology.



Gene_expression (expression) of Avp
10) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.52 Pain Relevance 0.07
In this study, we identified polymorphisms in the Avp gene underlying a decreased expression of Avp mRNA in the hypothalamus of LAB animals under basal conditions compared to HAB, NAB and F1 mice, irrespective of gender.
Gene_expression (expression) of Avp mRNA in hypothalamus associated with anxiety disorder
11) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.45 Pain Relevance 0.05
Several peptides, including arginine-vasopressin (AVP), neurotensin, and substance P, produce analgesia that is not mediated by opiate systems.
Gene_expression (produce) of arginine-vasopressin associated with opiate, analgesia and substance p
12) Confidence 0.77 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3671785 Disease Relevance 0 Pain Relevance 0.66
Taken together, these data indicate that Bi-proVSP is produced in the venom gland, gets cleaved into its 34-kDa active form (mature Bi-VSP), and is then stored in the venom sac.


Gene_expression (produced) of VSP in gland
13) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862700 Disease Relevance 0 Pain Relevance 0
Avp, oxytocin (Oxt) and Crh mRNA expression in the PVN did not change in fluoxetine-treated male Avpr1b KO or wild-type mice.
Gene_expression (expression) of Avp in PVN associated with targeted disruption and fluoxetine
14) Confidence 0.72 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.60 Pain Relevance 0.95
The data suggests that the Avpr1b is required to drive the HPA axis response to acute antidepressant treatment and provides further evidence of a sexual dichotomy in the regulation of PVN Avp/Oxt gene expression following antidepressant administration.
Gene_expression (expression) of Avp in PVN associated with antidepressant
15) Confidence 0.72 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.39 Pain Relevance 0.81
The application of similar breeding strategies in two different species (Rattus norvegicus and Mus musculus) resulted in similar findings concerning the identification of polymorphisms in and around the Avp gene and both the expression and release patterns of AVP.
Gene_expression (expression) of AVP
16) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.72 Pain Relevance 0.08
Due to the high expression of Avp and Oxt mRNAs in the hypothalamic PVN and SON, we focused on these nuclei in LAB, HAB, NAB or F1 animals.
Gene_expression (expression) of Avp associated with anxiety disorder
17) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.10 Pain Relevance 0.15
Polymorphic AVP alleles
Gene_expression (alleles) of AVP
18) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.30 Pain Relevance 0.09
We then studied the analgesia produced by OXY and by AVP using 3 nonapeptide analogues with antagonist properties: [Pen1, LpMePhe2, Thr4, Orn8]OXY (PLMPTO-OXY) that has anti-oxytocic properties in the uterine contraction assay, d(CH2)5Tyr(Me)AVP(dTM-AVP) which antagonizes the antidiuretic properties of AVP and d(CH2)5D-Ile2,Abu4-AVP (dIA-AVP) which antagonizes the vasopressor effects of AVP.
Gene_expression (antagonizes) of Abu4-AVP in uterine associated with antagonist and analgesia
19) Confidence 0.67 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3671785 Disease Relevance 0 Pain Relevance 1.11
We then studied the analgesia produced by OXY and by AVP using 3 nonapeptide analogues with antagonist properties: [Pen1, LpMePhe2, Thr4, Orn8]OXY (PLMPTO-OXY) that has anti-oxytocic properties in the uterine contraction assay, d(CH2)5Tyr(Me)AVP(dTM-AVP) which antagonizes the antidiuretic properties of AVP and d(CH2)5D-Ile2,Abu4-AVP (dIA-AVP) which antagonizes the vasopressor effects of AVP.
Gene_expression (antagonizes) of dIA-AVP in uterine associated with antagonist and analgesia
20) Confidence 0.67 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3671785 Disease Relevance 0 Pain Relevance 1.12

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