INT113037

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 3.89
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
cortex 1
nervous system 1
hippocampus 1
frontal cortex 1
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 246 100.00 Very High Very High Very High
Hippocampus 78 99.84 Very High Very High Very High
Nicotine 96 99.80 Very High Very High Very High
Central nervous system 50 99.04 Very High Very High Very High
Spinal cord 14 98.96 Very High Very High Very High
dorsal root ganglion 1 97.24 Very High Very High Very High
b2 receptor 50 96.76 Very High Very High Very High
antagonist 184 96.60 Very High Very High Very High
depression 316 96.44 Very High Very High Very High
amygdala 8 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 52 99.58 Very High Very High Very High
Sprains And Strains 14 98.52 Very High Very High Very High
Urological Neuroanatomy 7 98.52 Very High Very High Very High
Ganglion Cysts 1 97.24 Very High Very High Very High
Depression 379 96.44 Very High Very High Very High
Cancer Pain 2 86.24 High High
INFLAMMATION 130 85.44 High High
Adhesions 1 78.32 Quite High
Infection 35 73.68 Quite High
Decapitation 14 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together the present findings offer detailed information about the distribution of B1R mRNA in the primate brain and spinal cord and demonstrate a basal level of expression in the primate nervous system.
Transcription (distribution) of B1R mRNA in nervous system associated with spinal cord
1) Confidence 0.69 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966562 Disease Relevance 0.33 Pain Relevance 0.67
The mRNA expression profile of the humanized Bdkrb1 (hBkdrb1) allele is similar to that of the mouse Bdkrb1 (mBkdrb1) in the wild-type animal.
Transcription (expression) of Bdkrb1
2) Confidence 0.53 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.31 Pain Relevance 0.29
Expression of kinin receptor mRNAs was analyzed with reverse transcription and polymerase chain reaction.
Spec (analyzed) Transcription (Expression) of kinin receptor
3) Confidence 0.51 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.09 Pain Relevance 0
B1 receptor and BDNF mRNA expression was carried out through fluorescence-based real-time PCR.
Transcription (expression) of B1 receptor associated with b1 receptor
4) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.07 Pain Relevance 0.12
Of note, the increase of B1 receptor mRNA expression in mice submitted to forced swimming plus LPS treatment was completely absent in TNF?
Transcription (expression) of B1 receptor associated with b1 receptor
5) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.73 Pain Relevance 0.38
Our in vivo data were reinforced by real-time PCR experiments, which demonstrated a marked increase in B1 receptor mRNA expression in hippocampus, and notably, in the cortex of mice submitted to forced swimming plus LPS administration.
Transcription (expression) of B1 receptor in cortex associated with b1 receptor and hippocampus
6) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.58 Pain Relevance 0.77
The increased immobility time following LPS treatment was preceded by an enhancement of hippocampal and cortical B1 receptor mRNA expression (which were maximal at 1 h), and a marked production of TNF?
Transcription (expression) of B1 receptor associated with b1 receptor
7) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.65 Pain Relevance 0.44
Therefore, B1 receptor mRNA expression was measured in the hippocampus and frontal cortex of mice submitted to a session of forced swimming, followed by LPS administration (450 ?
Transcription (expression) of B1 receptor in frontal cortex associated with b1 receptor, urological neuroanatomy and hippocampus
8) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.10 Pain Relevance 0.67
p55 receptor-knockout mice, and increased B1 receptor mRNA expression was completely absent in this mouse strain.
Neg (absent) Transcription (expression) of B1 receptor associated with targeted disruption, b1 receptor and sprains and strains
9) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.63 Pain Relevance 0.39
Moreover, YM976 also suppresses nicotine-enhanced kinin receptor mRNA expression.
Transcription (expression) of kinin associated with nicotine
10) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.31 Pain Relevance 0.42
Therefore, B1 receptor mRNA expression was measured in the hippocampus and frontal cortex of mice submitted to a session of forced swimming, followed by LPS administration (450 ?
Transcription (expression) of B1 receptor in hippocampus associated with b1 receptor, urological neuroanatomy and hippocampus
11) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.10 Pain Relevance 0.67

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