INT113038

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 7.11
Pain Relevance 7.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
central nervous system 8
smooth muscle 5
smooth muscle cells 4
dorsal root ganglia 2
hearts 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 238 100.00 Very High Very High Very High
B1 receptor 65 100.00 Very High Very High Very High
Nicotine 768 99.98 Very High Very High Very High
bradykinin 383 98.28 Very High Very High Very High
cytokine 49 98.20 Very High Very High Very High
dexamethasone 88 98.08 Very High Very High Very High
Inflammation 286 97.04 Very High Very High Very High
Central nervous system 4 93.60 High High
agonist 108 90.24 High High
antagonist 93 89.76 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 49 99.90 Very High Very High Very High
Injury 19 99.56 Very High Very High Very High
Bacterial Infection 4 98.24 Very High Very High Very High
Nociception 3 97.72 Very High Very High Very High
INFLAMMATION 306 97.04 Very High Very High Very High
Pressure And Volume Under Development 25 94.20 High High
Asthma 121 93.24 High High
Nicotine Addiction 96 93.00 High High
Reperfusion Injury 128 91.08 High High
Myocardial Infarction 4 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Positive_regulation (over) of Gene_expression (expressing) of B1R in central nervous system associated with targeted disruption and central nervous system
1) Confidence 0.69 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
Liesmaa and collaborators identified increased expression of B1R in endothelium of failing human hearts.
Positive_regulation (increased) of Gene_expression (expression) of B1R in hearts
2) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.48 Pain Relevance 0.48
While B2R is constitutively expressed in many tissues, B1R expression is thought to be absent, but induced under proinflammatory conditions.
Positive_regulation (induced) of Gene_expression (expression) of B1R
3) Confidence 0.47 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966562 Disease Relevance 0.38 Pain Relevance 0.28
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Positive_regulation (expressing) of Gene_expression (over) of B1R in central nervous system associated with targeted disruption and central nervous system
4) Confidence 0.46 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Positive_regulation (expressing) of Gene_expression (expressing) of B1R in central nervous system associated with targeted disruption and central nervous system
5) Confidence 0.46 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Positive_regulation (over) of Gene_expression (over) of B1R in central nervous system associated with targeted disruption and central nervous system
6) Confidence 0.46 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
The expression of kinin B(1), but not B(2), receptor mRNA was markedly increased in the L4/5 dorsal root ganglia on the melanoma-bearing side.
Positive_regulation (increased) of Gene_expression (expression) of kinin B in dorsal root ganglia
7) Confidence 0.45 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.06 Pain Relevance 0
We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].
Positive_regulation (increased) of Gene_expression (deletion) of B1R
8) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.44 Pain Relevance 0.45
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Positive_regulation (performed) of Gene_expression (expression) of B1R
9) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
In B2KO, B1R expression was increased at 4 and 24 hours (Figure 1B).
Positive_regulation (increased) of Gene_expression (expression) of B1R
10) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.34 Pain Relevance 0.25
It is interesting to note that though kinin receptor protein expression was increased both on the epithelium and smooth muscle, bradykinin- and des-Arg9-bradykinin-induced relaxations were unaffected.
Positive_regulation (increased) of Gene_expression (expression) of kinin receptor protein in smooth muscle associated with bradykinin
11) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.42 Pain Relevance 0.54
An increase in kinin B1 (Fig. 5A-B) and B2 (Fig. 5C-D) receptor protein expressions were seen in both the airway epithelial and smooth muscle cells (Fig. 5E-F).
Positive_regulation (increase) of Gene_expression (expressions) of kinin in smooth muscle cells
12) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.41
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Positive_regulation (airway) of Gene_expression (expressions) of kinin associated with nicotine and b2 receptor
13) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.44
In the control segments, the expression of B1 receptors is higher in the epithelial cells compared to the smooth muscle cells; while after nicotine treatment, the increase in B1 receptor protein expression was more prominent in the smooth muscle cells than in the epithelial cells (Fig. 5E).
Positive_regulation (increase) of Gene_expression (expression) of B1 receptor in smooth muscle cells associated with b1 receptor and nicotine
14) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.38
Pharmacological inhibition of JNK abolished the nicotine-enhanced kinin B1 and B2 receptor-mediated contractions (Fig. 7A-B) and decreased the nicotine-enhanced kinin B1 and B2 receptor mRNA expressions (Fig. 4B).


Positive_regulation (enhanced) of Gene_expression (expressions) of kinin associated with nicotine and b2 receptor
15) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.09 Pain Relevance 0.76
The increase in maximal contraction, without significant change of pEC50, seen after 4 days of nicotine treatment suggests an increase in kinin receptor protein expression rather than alteration of receptor sensitivity.
Positive_regulation (increase) of Gene_expression (expression) of kinin receptor protein associated with nicotine
16) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.27 Pain Relevance 0.62
- and organ culture-induced kinin receptor expression in airway smooth muscle [22].
Positive_regulation (induced) of Gene_expression (expression) of kinin in smooth muscle
17) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.25 Pain Relevance 0.54
It is interesting to note that though kinin receptor protein expression was increased both on the epithelium and smooth muscle, bradykinin- and des-Arg9-bradykinin-induced relaxations were unaffected.
Positive_regulation (increased) of in epithelium Gene_expression (expression) of kinin receptor protein in smooth muscle associated with bradykinin
18) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.42 Pain Relevance 0.54
The B2 receptor is ubiquitous and constitutively expressed, whereas the B1 receptor is expressed at a very low level in healthy tissues but induced following injury by various proinflammatory cytokines such as interleukin-1beta.
Positive_regulation (induced) of Gene_expression (expressed) of B1 receptor associated with b1 receptor, injury, b2 receptor and cytokine
19) Confidence 0.09 Published 2005 Journal Pharmacol. Rev. Section Abstract Doc Link 15734727 Disease Relevance 0.59 Pain Relevance 0.73

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