INT113041

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 5.83
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (IHH) extracellular space (IHH) extracellular region (IHH)
plasma membrane (IHH) cell-cell signaling (IHH)
Anatomy Link Frequency
liver 3
pancreas 3
chondrocyte 1
scleral cells 1
parathyroid 1
IHH (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 14 100.00 Very High Very High Very High
Chronic pancreatitis 36 99.96 Very High Very High Very High
dexamethasone 189 93.96 High High
Osteoarthritis 32 60.08 Quite High
fibrosis 28 58.04 Quite High
anesthesia 25 50.56 Quite High
alcohol 10 38.16 Quite Low
Inflammation 64 5.00 Very Low Very Low Very Low
cytokine 55 5.00 Very Low Very Low Very Low
rheumatoid arthritis 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 36 99.96 Very High Very High Very High
Hypertrophy 30 96.40 Very High Very High Very High
Focal Cartilage Defect 5 93.52 High High
Targeted Disruption 6 89.24 High High
Diabetes Mellitus 8 87.28 High High
Fibrosis 20 85.68 High High
Disease 31 82.76 Quite High
Apoptosis 70 74.72 Quite High
Infection 20 72.44 Quite High
Hepatitis C Virus Infection 24 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IHH mRNA was expressed in the normal human pancreas and CP tIssues, with slightly higher expression levels in CP.
Gene_expression (expressed) of IHH mRNA in pancreas associated with chronic pancreatitis
1) Confidence 0.78 Published 2003 Journal J. Endocrinol. Section Abstract Doc Link 12967338 Disease Relevance 0.73 Pain Relevance 0.59
Specifically, we evaluated the expression patterns of Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c), which contains a GC response element in its promoter [57], Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) over 0, 6, 12, and 24 hrs of culture with or without DEX treatment.
Gene_expression (expression) of Indian hedgehog associated with metalloproteinase and dexamethasone
2) Confidence 0.75 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.21
In conclusion, IHH and its receptors are expressed in the normal human pancreas and in CP, yet with a different distribution and cellular localization.
Gene_expression (expressed) of IHH in pancreas associated with chronic pancreatitis
3) Confidence 0.68 Published 2003 Journal J. Endocrinol. Section Abstract Doc Link 12967338 Disease Relevance 0.77 Pain Relevance 0.69
In the present study, the expression of IHH and its receptors was analyzed in normal human pancreatic and chronic pancreatitis (CP) tIssues using Northern blotting, immunohistochemistry and Western blotting, and was correlated with clinicopathological parameters.
Spec (analyzed) Gene_expression (expression) of IHH associated with chronic pancreatitis
4) Confidence 0.68 Published 2003 Journal J. Endocrinol. Section Abstract Doc Link 12967338 Disease Relevance 0.45 Pain Relevance 0.45
Probes for Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c, p57), Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) were assayed using the TaqMan® gene expression assays in accordance with the manufacturers directions.
Gene_expression (expression) of Indian hedgehog associated with metalloproteinase
5) Confidence 0.65 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.09
In CP, IHH and its receptors were present in the cells forming tubular complexes and in the islets with a different signal pattern compared with the islets in the normal pancreas.
Gene_expression (present) of IHH in pancreas associated with chronic pancreatitis
6) Confidence 0.53 Published 2003 Journal J. Endocrinol. Section Abstract Doc Link 12967338 Disease Relevance 0.83 Pain Relevance 0.66
Total positive associations (AUC-ROC, 1.000) were found between IHH and three of the five expressed genes (SHH, GLI1, and GLI4).


Gene_expression (expressed) of IHH
7) Confidence 0.47 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.31 Pain Relevance 0.05
To further explore the Hedgehog-Gli signaling pathway to discriminate between groups A and B, we tested the expression of six additional genes involved in this pathway (DHH, SHH, GLI1, GLI2, GLI3, and GLI4) in three high IHH-expressing percutaneous normal liver samples and three low IHH-overexpressing surgical nontumoral liver samples.
Gene_expression (expressing) of IHH in liver
8) Confidence 0.41 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.55 Pain Relevance 0.03
To further explore the Hedgehog-Gli signaling pathway to discriminate between groups A and B, we tested the expression of six additional genes involved in this pathway (DHH, SHH, GLI1, GLI2, GLI3, and GLI4) in three high IHH-expressing percutaneous normal liver samples and three low IHH-overexpressing surgical nontumoral liver samples.
Gene_expression (expressing) of IHH-overexpressing in liver
9) Confidence 0.41 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.54 Pain Relevance 0.03
To further explore the Hedgehog-Gli signaling pathway to discriminate between groups A and B, we tested the expression of six additional genes involved in this pathway (DHH, SHH, GLI1, GLI2, GLI3, and GLI4) in three high IHH-expressing percutaneous normal liver samples and three low IHH-overexpressing surgical nontumoral liver samples.
Gene_expression (expression) of IHH in liver
10) Confidence 0.41 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.63 Pain Relevance 0.03
IHH is expressed in prehypertrophic chondrocytes of the growth plate and functions to inhibit chondrocyte hypertrophy by maintaining expression of PTHrP through a negative feedback loop [91,92].
Gene_expression (expressed) of IHH in chondrocyte associated with hypertrophy
11) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.52 Pain Relevance 0.03
During development of the limbs and other bony tissues, chondrogenesis is gradually replaced by endochondral ossification as described above, with indian hedgehog (IHH), parathyroid hormone related peptide (PTHrP) and Wnt/?
Gene_expression (/) of IHH in parathyroid
12) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.40 Pain Relevance 0.03
After in vitro chondrogenesis of scleral cells, COL10A, SOX5, IHH, and MMP13 mRNA expressions increased.
Gene_expression (expressions) of IHH in scleral cells
13) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2579486 Disease Relevance 0.09 Pain Relevance 0

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