INT113063

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdk20) cell cycle (Cdk20) cilium (Cdk20)
cell division (Cdk20) kinase activity (Cdk20) cytoplasm (Cdk20)
Cdk20 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 99.08 Very High Very High Very High
agonist 1 97.36 Very High Very High Very High
Morphine 11 88.40 High High
tolerance 5 75.00 Quite High
Analgesic 3 75.00 Quite High
analgesia 1 71.52 Quite High
Anterior cingulate 3 66.56 Quite High
Locus ceruleus 3 60.88 Quite High
Nucleus accumbens 1 55.20 Quite High
amygdala 4 52.80 Quite High
Disease Link Frequency Relevance Heat
Stress 9 63.76 Quite High
Reprotox - General 1 39 35.28 Quite Low
Cancer 19 15.84 Low Low
Aging 1 10.08 Low Low
Disease 2 7.04 Low Low
Apoptosis 25 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid-receptor activation in cell lines results in phosphorylation of p42/44 mitogen-activated protein kinase (MAPK), which contributes to agonist-induced desensitization of adenylate cyclase signaling.
Phosphorylation (phosphorylation) of p42 associated with agonist and opioid
1) Confidence 0.80 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12967998 Disease Relevance 0 Pain Relevance 0.78
The interactions between MAP kinase and its immediate upstream kinase (MAPKK) are highly specific: for instance, p42/p44 MAP kinases are phosphorylated solely by MAP/ERK kinase (MEK) 1 and 2; p38 MAP kinase is selectively activated by MAP kinase kinases (MKK) 3 and 6, while JNK is activated by MKK7 and MKK4 in most conditions, however MKK4 can sometimes activate p38 MAP kinase when over expressed.
Phosphorylation (phosphorylated) of p42
2) Confidence 0.07 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.17 Pain Relevance 0

General Comments

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