INT11307

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 7.86
Pain Relevance 11.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
body 1
pcp (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 43 100.00 Very High Very High Very High
cocaine 13 100.00 Very High Very High Very High
Cancer pain 7 100.00 Very High Very High Very High
substance P 4 99.84 Very High Very High Very High
Paracetamol 12 99.58 Very High Very High Very High
Morphine 44 99.36 Very High Very High Very High
agonist 21 99.28 Very High Very High Very High
GABA receptor 6 99.10 Very High Very High Very High
narcan 12 99.06 Very High Very High Very High
Eae 14 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 31 100.00 Very High Very High Very High
Emergencies 4 100.00 Very High Very High Very High
Apoptosis 10 99.98 Very High Very High Very High
Influenza Virus Infection 164 98.94 Very High Very High Very High
Body Weight 29 98.76 Very High Very High Very High
Colon Cancer 94 97.24 Very High Very High Very High
Death 49 97.16 Very High Very High Very High
Adult Respiratory Distress Syndrome 24 92.84 High High
Pulmonary Hypertension 3 91.92 High High
Ataxia 4 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that acute administration of morphine enhances a variety of pharmacological effects of PCP; an inhibition of PCP disposition by morphine may be a mechanism involved in this process.
Negative_regulation (inhibition) of PCP associated with morphine
1) Confidence 0.48 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.14 Pain Relevance 1.05
These data indicate that PCP is more effective in decreasing the sulfation of low than high doses of AA, which may result from less AA, at lower doses, to compete with PCP for sulfotransferases.
Negative_regulation (compete) of PCP associated with paracetamol
2) Confidence 0.43 Published 2000 Journal Toxicology Section Abstract Doc Link 10773360 Disease Relevance 0 Pain Relevance 1.01
These results suggest that metaphit produces a functional antagonism of PCP-induced locomotor activity through presynaptic mechanisms unrelated to specific blockade of PCP receptors.
Negative_regulation (blockade) of PCP associated with eae
3) Confidence 0.38 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2820762 Disease Relevance 0.23 Pain Relevance 0.31
Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors.
Negative_regulation (blockade) of PCP associated with antagonist
4) Confidence 0.38 Published 1987 Journal Eur. J. Pharmacol. Section Title Doc Link 2820762 Disease Relevance 0.21 Pain Relevance 0.29
Yohimbine and methysergide also blocked PCP in high dosages, but other drugs with comparable alpha-noradrenergic and serotonergic blocking properties (phentolamine, cyproheptadine, and cinnanserin) were ineffective.
Negative_regulation (blocked) of PCP
5) Confidence 0.38 Published 1980 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6109351 Disease Relevance 0 Pain Relevance 0.29
The GABA receptor agonists imidazole acetic acid and muscimol blocked PCP, but other drugs that influence GABA, such as dipropylacetic acid, baclofen, and diazepam, were ineffective.
Negative_regulation (blocked) of PCP associated with gaba, gaba receptor and agonist
6) Confidence 0.38 Published 1980 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6109351 Disease Relevance 0 Pain Relevance 0.25
These findings suggest that chlorpromazine, clozapine, yohimbine, and methysergide may share a property that is unlike their primary known modes of action on dopaminergic, alpha-noradrenergic, and serotonergic neurotransmitter systems, and that this property accounts for their ability to block PCP.
Negative_regulation (block) of PCP associated with neurotransmitter
7) Confidence 0.38 Published 1980 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6109351 Disease Relevance 0 Pain Relevance 0.42
A reduction in the median number of days in the PCP may be an indication of less time available to affect planned, coordinated and integrated care in a way that might minimize transitions for patients.
Negative_regulation (reduction) of PCP
8) Confidence 0.37 Published 2006 Journal BMC Palliat Care Section Body Doc Link PMC1557663 Disease Relevance 0.42 Pain Relevance 0.08
Contrary to these, PCP-related emergency room mentions in the County were decreased from 1,259 in the first six months of 1982 to 630 in those of 1989.
Negative_regulation (decreased) of PCP associated with emergencies
9) Confidence 0.37 Published 1994 Journal Nihon Hoigaku Zasshi Section Abstract Doc Link 8065069 Disease Relevance 0.73 Pain Relevance 0.50
NCPB abolished celiac PCP in 70-80% of patients immediately after the block and in 60-75% until death.
Negative_regulation (abolished) of PCP associated with cancer pain and death
10) Confidence 0.37 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1550278 Disease Relevance 1.71 Pain Relevance 1.23
CONCLUSION: This procedure decreases the incidence of physical activity-induced PCP, without increasing the risks of sensory changes.


Negative_regulation (decreases) of PCP
11) Confidence 0.37 Published 2010 Journal Hernia Section Body Doc Link 19826895 Disease Relevance 0.14 Pain Relevance 0
LVEDP, PCP, and TPR were markedly decreased.
Negative_regulation (decreased) of PCP
12) Confidence 0.37 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2475700 Disease Relevance 0.15 Pain Relevance 0.08
Rather the increased staining in the P2+P7 animals indicates that PCP exposure at P2 has produced alterations in the brain that result in it being more susceptible to the apoptotic effects of PCP at P7.
Negative_regulation (effects) of PCP in brain associated with apoptosis
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.25 Pain Relevance 0.12
Animals treated with a single dose of PCP on P2 weighed significantly less than either normal (suckle) (p?
Negative_regulation (dose) of PCP
14) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.22 Pain Relevance 0.06
The LD50 of PCP was significantly decreased in the presence of morphine.
Negative_regulation (decreased) of PCP associated with morphine
15) Confidence 0.35 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.15 Pain Relevance 1.01
The ratio of the liver weight to body weight and aniline hydroxylase activity in hepatic microsomal fraction were decreased in the morphine-treated group compared with the control group; this is indicative of a possible reduction in the oxidative metabolism of PCP.
Spec (possible) Negative_regulation (reduction) of PCP in body associated with body weight and morphine
16) Confidence 0.35 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.16 Pain Relevance 1.11
The detection limit of PCP was approximately 15 pg on-column (0.75 ng/ml sample), which was much lower than by GC-nitrogen phosphorus detection.
Negative_regulation (limit) of PCP
17) Confidence 0.34 Published 1996 Journal Int. J. Legal Med. Section Abstract Doc Link 8721423 Disease Relevance 0 Pain Relevance 0.18
Results indicate that bremazocine dose dependently reduced cocaine, ethanol, PCP, and saccharin intake.
Negative_regulation (reduced) of PCP associated with cocaine
18) Confidence 0.32 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12023530 Disease Relevance 0 Pain Relevance 0.49
RESULTS: In an open economy, naltrexone nonselectively suppressed ethanol, PCP, and food-maintained behavior, in contrast to results in the previous study which used a closed economy, wherein naltrexone did not significantly suppress food- or PCP self-administration.
Negative_regulation (suppressed) of PCP
19) Confidence 0.31 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10928315 Disease Relevance 0 Pain Relevance 0
These results suggest that metaphit acts not as an antagonist of PCP but as a PCP-like agonist under these conditions.
Neg (not) Negative_regulation (antagonist) of PCP associated with antagonist and agonist
20) Confidence 0.23 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3009781 Disease Relevance 0.33 Pain Relevance 0.34

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