INT113077

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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
withdrawal 18 99.96 Very High Very High Very High
Dopamine 4 99.72 Very High Very High Very High
Morphine 16 98.74 Very High Very High Very High
narcan 4 92.52 High High
opiate 2 86.72 High High
Nucleus accumbens 6 80.88 Quite High
addiction 2 78.52 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 78.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During precipitated withdrawal, D1 receptor-mediated CREB phosphorylation was dependent on cAMP-dependent protein kinase (PKA).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of D1 receptor associated with withdrawal
1) Confidence 0.11 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.07 Pain Relevance 1.42
Precipitated morphine withdrawal was associated with enhanced dopamine-, SKF 82958 (D1 receptor agonist)-, and forskolin-induced CREB phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of D1 receptor associated with dopamine, agonist, withdrawal and morphine
2) Confidence 0.11 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.08 Pain Relevance 1.44

General Comments

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