INT113078

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.77
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
NAc 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 7 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
withdrawal 23 99.96 Very High Very High Very High
Glutamate receptor 2 98.82 Very High Very High Very High
Morphine 23 98.74 Very High Very High Very High
Nucleus accumbens 13 96.52 Very High Very High Very High
nMDA receptor 5 95.28 Very High Very High Very High
addiction 6 93.28 High High
narcan 9 92.52 High High
Hippocampus 22 87.04 High High
Disease Link Frequency Relevance Heat
Morphine Dependence 4 94.00 High High
Stress 67 91.20 High High
Depression 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Glioma 2 5.00 Very Low Very Low Very Low
Depressive Disorder 1 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).
Phosphorylation (phosphorylation) of D1 receptor in NAc associated with nucleus accumbens, dopamine and glutamate receptor
1) Confidence 0.30 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.18 Pain Relevance 1.22
During precipitated withdrawal, D1 receptor-mediated CREB phosphorylation was dependent on cAMP-dependent protein kinase (PKA).
Phosphorylation (phosphorylation) of D1 receptor associated with withdrawal
2) Confidence 0.15 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.07 Pain Relevance 1.42
Precipitated morphine withdrawal was associated with enhanced dopamine-, SKF 82958 (D1 receptor agonist)-, and forskolin-induced CREB phosphorylation.
Phosphorylation (phosphorylation) of D1 receptor associated with dopamine, agonist, withdrawal and morphine
3) Confidence 0.15 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.08 Pain Relevance 1.44
Interestingly, dopamine D1 receptor-mediated CREB phosphorylation appears to involve NMDA NR1 subunit phosphorylation [61].
Phosphorylation (phosphorylation) of dopamine D1 associated with dopamine
4) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.44 Pain Relevance 0.37

General Comments

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