INT113080

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.43
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Drd1a, Creb1) nucleoplasm (Creb1) mitochondrion (Creb1)
endoplasmic reticulum (Drd1a) intracellular (Drd1a) DNA binding (Creb1)
Anatomy Link Frequency
NAc 4
Drd1a (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 6 100.00 Very High Very High Very High
Glutamate receptor 2 100.00 Very High Very High Very High
withdrawal 19 99.96 Very High Very High Very High
Nucleus accumbens 17 98.36 Very High Very High Very High
agonist 5 96.80 Very High Very High Very High
Morphine 22 94.64 High High
addiction 9 93.92 High High
narcan 12 88.56 High High
opiate 3 82.76 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 5 94.64 High High
Substance Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low
Opiate Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).
D1 receptor Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CREB in NAc associated with nucleus accumbens, dopamine and glutamate receptor
1) Confidence 0.27 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.18 Pain Relevance 1.23
In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).
D1 receptor Positive_regulation (mediated) of Phosphorylation (phosphorylation) of P-CREB in NAc associated with nucleus accumbens, dopamine and glutamate receptor
2) Confidence 0.23 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.18 Pain Relevance 1.22
During precipitated withdrawal, D1 receptor-mediated CREB phosphorylation was dependent on cAMP-dependent protein kinase (PKA).
D1 receptor Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CREB associated with withdrawal
3) Confidence 0.14 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.07 Pain Relevance 1.42

General Comments

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