INT113100

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.38
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl11) extracellular region (Ccl11) cytoskeleton organization (Ccl11)
Anatomy Link Frequency
plasma 1
eosinophil 1
Ccl11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 100.00 Very High Very High Very High
chemokine 8 97.84 Very High Very High Very High
cytokine 92 87.92 High High
Inflammatory response 14 77.28 Quite High
tolerance 22 72.56 Quite High
cINOD 1 50.00 Quite Low
lidocaine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 100.00 Very High Very High Very High
Asthma 70 100.00 Very High Very High Very High
Disease 82 99.64 Very High Very High Very High
Pulmonary Disease 120 99.40 Very High Very High Very High
Nicotine Addiction 104 98.48 Very High Very High Very High
Eosinophilia 6 84.72 Quite High
Disease Progression 16 84.20 Quite High
Adhesions 8 82.88 Quite High
Bronchial Hyperreactivity 2 82.00 Quite High
Death 20 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A compound preparation of traditional Chinese medicine inhibited eotaxin mRNA and eosinophil infiltration, influenced TNF-alpha mRNA expression.
Negative_regulation (inhibited) of eotaxin in eosinophil
1) Confidence 0.58 Published 2003 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 12970926 Disease Relevance 0 Pain Relevance 0
Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
Negative_regulation (regulation) of Ccl11 associated with asthma, nicotine addiction and inflammation
2) Confidence 0.40 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.15 Pain Relevance 0.47
Eotaxin-1 levels, on the other hand, were significantly lower in the stable COPD group (Figure 5) compared to normal controls (p < 0.03) and trended lower in stable COPD subjects compared to those with rapidly progressive disease (p = 0.11).
Negative_regulation (lower) of Eotaxin-1 associated with pulmonary disease and disease
3) Confidence 0.28 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.40 Pain Relevance 0.16
In addition, disease stability was associated with decreased plasma eotaxin-1 levels.
Negative_regulation (decreased) of eotaxin-1 in plasma associated with disease
4) Confidence 0.28 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.38 Pain Relevance 0.17
The qRT-PCR analysis of these samples verified results for Ccl8 and indicated a down-regulation of 10 other asthma-related genes (Arg1, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2) in EOO versus AOO mice (Table 2).
Negative_regulation (down-regulation) of Ccl11 associated with asthma
5) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.44 Pain Relevance 0.15

General Comments

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