INT113107

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 8.01
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hist1h3f) molecular_function (Hist1h3f) biological_process (Hist1h3f)
Anatomy Link Frequency
neurons 2
neuronal 1
striatum 1
intestinal epithelium 1
arms 1
Hist1h3f (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 27 98.42 Very High Very High Very High
cocaine 12 98.24 Very High Very High Very High
mu opioid receptor 80 97.08 Very High Very High Very High
Nucleus accumbens 82 96.36 Very High Very High Very High
fluoxetine 9 93.44 High High
opiate 1 92.44 High High
antagonist 32 90.32 High High
Dopamine 140 89.92 High High
cytokine 127 89.32 High High
Eae 31 84.00 Quite High
Disease Link Frequency Relevance Heat
Stress 43 100.00 Very High Very High Very High
Infection 12 98.96 Very High Very High Very High
Cancer 247 98.66 Very High Very High Very High
Apoptosis 92 97.44 Very High Very High Very High
Necrosis 13 96.56 Very High Very High Very High
Targeted Disruption 85 95.04 Very High Very High Very High
Hyperplasia 6 92.68 High High
Bladder Cancer 1 92.44 High High
Intellectual Impairment 3 92.00 High High
Skin Cancer 5 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, chromatin immunoprecipitation studies did not reveal any changes in the acetylation or trimethylation of histone H3 at the BDNF promoters.
Phosphorylation (acetylation) of histone H3
1) Confidence 0.51 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18973993 Disease Relevance 0.40 Pain Relevance 0.86
Activated ERK, in turn, induces CREB phosphorylation, c-Fos expression, mitogen- and stress-activated kinase-1 (MSK1) activation and histone H3 phosphorylation, all of which further regulate gene expression in D1 receptor-expressing neurons [42], [43].
Phosphorylation (phosphorylation) of histone H3 in neurons associated with stress
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.18 Pain Relevance 0.28
We examined the phosphorylation of histone H3 which is tightly correlated with the chromosome condensation phase during mitosis, thereby representing a snapshot of cells in M phase of cell cycle41.
Spec (examined) Phosphorylation (phosphorylation) of histone H3
3) Confidence 0.33 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.67 Pain Relevance 0.03
Second, we observed a profound decrease in cell proliferation as measured by staining for the phosphorylated Histone H3 (HH3, Figures 2C & 2D; group effect: F3,11?
Phosphorylation (phosphorylated) of Histone H3
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.39 Pain Relevance 0
Activated ERK, in turn, induces CREB phosphorylation, c-Fos expression, mitogen- and stress-activated kinase-1 (MSK1) activation and histone H3 phosphorylation, all of which further regulate gene expression in D1 receptor-expressing neurons [42], [43].
Phosphorylation (phosphorylation) of histone H3 in neurons associated with stress
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.18 Pain Relevance 0.24
Analysis of cell cycle activity in these hearts by examination of phosphorylated histone H3 in 3-day-old mice revealed significantly less reactivity in CnB1fl/flcTnT-Cre mice when compared with controls, again suggesting that loss of CnB1 from the heart negatively affected cellular proliferation (Fig. 6, H and I).



Phosphorylation (phosphorylated) of histone H3 in heart associated with hyperplasia
6) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.16 Pain Relevance 0
The lack of ERK activation in neurons expressing D2R may result from a negative effect of D2R on ERK activation, since pharmacological blockade of D2Rs by haloperidol or raclopride selectively activates ERK and induces histone H3 phosphorylation in D2R-expressing striatopallidal MSNs in the dorsal striatum (Bertran-Gonzalez et al., 2008, 2009).
Phosphorylation (phosphorylation) of histone H3 in striatum
7) Confidence 0.24 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.14 Pain Relevance 0.30
ERK activation induces the phosphorylation in the nucleus of mitogen- and stress-activated kinase-1 (MSK1) and histone H3, responses that are also restricted to D1R-expressing MSNs of the dorsal striatum and the NAc after cocaine (Bertran-Gonzalez et al., 2008).
Phosphorylation (phosphorylation) of histone H3 in nucleus associated with stress, nucleus accumbens and cocaine
8) Confidence 0.24 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.17 Pain Relevance 0.30
The effects of VPA on acetylation of histone H3 and ?
Phosphorylation (acetylation) of histone H3
9) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.37 Pain Relevance 0
Tumor proliferation was analyzed by immunohistochemical localization of phosphorylated histone-H3, indicating cells undergoing mitotic division (Figure 6F-H).
Spec (analyzed) Phosphorylation (phosphorylated) of histone-H3 associated with cancer
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 1.98 Pain Relevance 0
These cells are accordingly in G2 and show prophase-like condensation but are different from normal prophases on a molecular level, because in normal prophases histone H3-phosphorylation has spread out over the whole chromosome arms (see Figure S2 for an exemplary normal prophase cell).
Phosphorylation (phosphorylation) of histone H3 in arms
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
The Rsk2 gene encodes a serine/threonine kinase that is activated by and acts downstream of MAPK/ERK via a dual function in CRE-mediated transcriptional regulation and in chromating remodeling by phosphorylating histone H3.
Phosphorylation (phosphorylating) of histone H3
12) Confidence 0.16 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.32 Pain Relevance 0
It has been well established that the Zn2+-finger-containing protein REST/NRSF binds the 21 bp NRSE DNA element found in many neuronal genes including MOR and then nucleates the formation of a multiprotein complex that represses gene transcription by deacetylating histones, methylating both DNA and histone H3, and dephosphorylation of RNA polymerase II (15,18,33).
Phosphorylation (dephosphorylation) of histone H3 in neuronal associated with mu opioid receptor
13) Confidence 0.15 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.14 Pain Relevance 0.15
To this end, we examined the expression of two endogenous cell cycle markers in relation to BrdU: proliferating cell nuclear antigen (PCNA) and phosphorylated histone H3 (pHisH3).
Phosphorylation (phosphorylated) of phosphorylated histone H3
14) Confidence 0.12 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15160390 Disease Relevance 0 Pain Relevance 0.30
By contrast, Stat3 ablation in intestinal epithelium in vivo or in tumour cell lines in vitro resulted in cell cycle arrest in the G2/M transition and is associated with histone H3 phosphorylation-associated mitotic arrest [68].
Phosphorylation (phosphorylation) of histone H3 in intestinal epithelium associated with cancer
15) Confidence 0.11 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.01 Pain Relevance 0.03
such as phosphorylated histone H3, phosphorylated RNA polymerase
Phosphorylation (phosphorylated) of histone H3
16) Confidence 0.10 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.31 Pain Relevance 0.03
such as phosphorylated histone H3, phosphorylated RNA polymerase
Phosphorylation (phosphorylated) of histone H3
17) Confidence 0.10 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.31 Pain Relevance 0.03
Histone H3 phosphorylation was elevated after virus infection and decreased in the presence of morphine.
Phosphorylation (phosphorylation) of Histone H3 associated with infection and morphine
18) Confidence 0.08 Published 2003 Journal Cell Biol. Int. Section Abstract Doc Link 12972276 Disease Relevance 0.49 Pain Relevance 0.76
Apoptosis induced by SIVmac239 and the effects of morphine were analyzed by flow cytometry. cAMP levels, PKA activity, and the resulting histone H3 phosphorylation levels were measured.
Phosphorylation (phosphorylation) of histone H3 associated with apoptosis and morphine
19) Confidence 0.08 Published 2003 Journal Cell Biol. Int. Section Abstract Doc Link 12972276 Disease Relevance 0.47 Pain Relevance 0.71
Immunostaining for the metaphase marker phosphorylated histone H3 indicates that the highly compacted cells are mitotic (unpublished data).
Phosphorylation (phosphorylated) of histone H3
20) Confidence 0.08 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0

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