INT113110

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.01
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
stromal cell 2
gonads 1
stem cells 1
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 248 100.00 Very High Very High Very High
Opioid 6 99.56 Very High Very High Very High
opiate 3 98.74 Very High Very High Very High
metalloproteinase 117 94.64 High High
antagonist 29 92.88 High High
Inflammation 84 92.52 High High
cytokine 91 91.84 High High
opioid receptor 2 88.32 High High
trk B 1 87.36 High High
Inflammatory response 8 85.44 High High
Disease Link Frequency Relevance Heat
Breast Cancer 67 99.60 Very High Very High Very High
Infection 115 99.38 Very High Very High Very High
Leukemia 21 98.76 Very High Very High Very High
Cancer 557 97.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 31 96.72 Very High Very High Very High
INFLAMMATION 100 92.52 High High
Mantle-cell Lymphoma 2 85.44 High High
Hematological Disease 14 84.32 Quite High
Glioma 5 83.76 Quite High
Adhesions 86 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlabeled CXCL12 and the well-known CXCR4 inhibitors, AMD3100 and T22, blocked the binding of CXCL12(AF647) to SupT1 cells with 50% inhibitory concentrations of 92, 13, and 8 ng/ml, respectively.
Negative_regulation (inhibitors) of CXCL12
1) Confidence 0.43 Published 2004 Journal Cytometry A Section Body Doc Link 15382150 Disease Relevance 0.19 Pain Relevance 0
Opiates are important co-factors for progression to neuroAIDS and can disrupt the CXCL12/CXCR4 axis in vitro and in vivo.
Negative_regulation (disrupt) of CXCL12 associated with opiate
2) Confidence 0.41 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20627326 Disease Relevance 0.19 Pain Relevance 0.35
However, blocking the CXCL12/CXCR4
Negative_regulation (blocking) of CXCL12
3) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.37 Pain Relevance 0.05
In mice lacking CXCL12, the colonization of gonads by PGCs is impaired [103].
Negative_regulation (lacking) of CXCL12 in gonads
4) Confidence 0.33 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.70 Pain Relevance 0
Therefore, the activity of isoform-selective PI3K inhibitors was investigated to indirectly block CXCL12/CXCR4 signals in chronic cell leukemia leading migration, stromal cell interactions, and stromal cell-mediated drug resistance [136].
Spec (investigated) Negative_regulation (block) of CXCL12 in stromal cell associated with leukemia
5) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.31 Pain Relevance 0
A second study demonstrated that genistein is able to downregulate the levels of the chemokine receptors CXCR4 and CXCL12 when the breast cancer cells were treated with low micromolar concentrations of genistein [162].
Negative_regulation (downregulate) of CXCL12 associated with chemokine and breast cancer
6) Confidence 0.27 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.81 Pain Relevance 0.10
We found that the chemotactic responses to the CCR1/5 ligand CCL5/regulated on activation, normal T expressed and secreted, but not the CXCR4 ligand stromal cell-derived factor-1alpha/CXCL12 were inhibited following opioid pretreatment.
Negative_regulation (inhibited) of CXCL12 in stromal cell associated with opioid
7) Confidence 0.20 Published 2003 Journal J. Leukoc. Biol. Section Abstract Doc Link 12972507 Disease Relevance 0.44 Pain Relevance 0.56
Representative data from one time point of infection shows that there was complete inhibition of SDF-1, SCF, TGF-?
Negative_regulation (inhibition) of SDF-1 associated with infection
8) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.84 Pain Relevance 0.45
Previous reports have indicated that elevated FGF2 decreased both stromal cell derived factor-1 (SDF-1;CXCL12) mRNA and protein in vivo and also diminished the capacity of BMSC to support the expansion of peripheral blood derived stem cells[53].
Negative_regulation (decreased) of SDF-1 in stem cells
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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