INT113111

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 12.81
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
colon 1
osteoblasts 1
neural 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 618 100.00 Very High Very High Very High
Opioid 5 99.92 Very High Very High Very High
antagonist 95 95.96 Very High Very High Very High
opioid receptor 2 92.32 High High
opiate 1 87.88 High High
Dopamine 83 81.32 Quite High
Inflammation 106 80.32 Quite High
midbrain 20 79.04 Quite High
cytokine 24 72.00 Quite High
agonist 30 53.48 Quite High
Disease Link Frequency Relevance Heat
Syndrome 46 99.90 Very High Very High Very High
Cancer 1392 99.84 Very High Very High Very High
Ovarian Cancer 445 99.84 Very High Very High Very High
Breast Cancer 177 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 48 99.36 Very High Very High Very High
Muscular Dystrophy 140 99.20 Very High Very High Very High
Mantle-cell Lymphoma 5 99.00 Very High Very High Very High
Metastasis 309 98.16 Very High Very High Very High
Leukemia 52 97.96 Very High Very High Very High
Multiple Myeloma 5 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
breast cancer in which interventions affecting CXCR4 reduced both growth of the
Regulation (affecting) of CXCR4 associated with breast cancer
1) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.39 Pain Relevance 0.04
It could be possible that a deregulated CXCR4/CXCR7/CXCL12 axis could be already evident in early stage of illness.

8.

Regulation (deregulated) of CXCR4
2) Confidence 0.47 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.89 Pain Relevance 0
All the data previously discussed provide the rationale for targeting CXCR4 in cancer.
Regulation (targeting) of CXCR4 associated with cancer
3) Confidence 0.47 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.95 Pain Relevance 0
adult, CXCL12 and CXCR4 are involved in the homing and retention of
Regulation (involved) of CXCR4
4) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.17 Pain Relevance 0.07
In

our studies of the possible effects of these different prostaglandins on CXCR4,

Spec (possible) Regulation (effects) of CXCR4
5) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.42 Pain Relevance 0.03
group demonstrated the importance of the CXCL12/CXCR4 axis in site-specific
Regulation (importance) of CXCR4
6) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.17 Pain Relevance 0.04
Therefore, targeting the CXCR4/CXCL12 axis is attractive therapeutic approach in leukemia patients.
Regulation (targeting) of CXCR4 associated with leukemia
7) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.43 Pain Relevance 0
In the present report, we sought to examine the capacity of mu- and delta-opioids to modulate the function of chemokine receptors CCR5 and CXCR4, the two major human immunodeficiency virus (HIV) coreceptors.
Spec (examine) Regulation (modulate) of CXCR4 associated with chemokine, acquired immune deficiency syndrome or hiv infection and opioid
8) Confidence 0.32 Published 2003 Journal J. Leukoc. Biol. Section Abstract Doc Link 12972507 Disease Relevance 0.35 Pain Relevance 0.52
from osteoblasts has also been shown to act on CXCR4 to induce release of IL-6
Regulation (act) of CXCR4 in osteoblasts
9) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.16 Pain Relevance 0
Moreover, we observed that the nature of the dystrophin gene mutation did not affect the levels of both CD133+CXCR4+CD34- and CD133+CXCR4+CD34+ cells in the DMD subjects analyzed in this study.
Neg (not) Regulation (affect) of CXCR4 associated with muscular dystrophy
10) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.78 Pain Relevance 0
Moreover, we observed that the nature of the dystrophin gene mutation did not affect the levels of both CD133+CXCR4+CD34- and CD133+CXCR4+CD34+ cells in the DMD subjects analyzed in this study.
Neg (not) Regulation (affect) of CXCR4 associated with muscular dystrophy
11) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.78 Pain Relevance 0
The middle SMS-REP/LCR17pB was also insertion target of the MDLS region in patient 1.
Regulation (target) of LCR associated with syndrome
12) Confidence 0.26 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.43 Pain Relevance 0
Eight genes perfectly discriminated between groups A and B (AUC-ROC, 1.000): seven up-regulated genes (PAI1, THBS1, IL8, PTGS2, CXCR4, JUN, and FOS) and one down-regulated gene (IHH).
Regulation (regulated) of CXCR4
13) Confidence 0.22 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.20 Pain Relevance 0.04
In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies.
Regulation (target) of CXCR4 associated with cancer and antagonist
14) Confidence 0.21 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2798669 Disease Relevance 0.72 Pain Relevance 0.29
The lack of influence of CXCR4 in ovarian cancer could reflect the peculiar characteristics of the metastatic process in ovarian cancer as compared to other cancers such as colon [88], non-small-cell lung cancer [89], gliomas [90], malignant melanomas [28], oral squamous carcinoma [91], and adult acute myeloid leukemia [92].
Regulation (influence) of CXCR4 in colon associated with squamous cell carcinoma, leukemia, lung cancer, melanoma, cancer, ovarian cancer and glioma
15) Confidence 0.21 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.90 Pain Relevance 0
Up-regulation of SDF-1 and its receptor CXCR4 was also observed during differentiation of neural stem cells into more restricted precursors [55].
Regulation (regulation) of CXCR4 in neural
16) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.08 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox