INT113112

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 28.28
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
stromal cell 2
lung 2
neuronal 1
vasculature 1
leukocyte 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 962 100.00 Very High Very High Very High
opiate 7 99.82 Very High Very High Very High
Inflammation 251 99.68 Very High Very High Very High
Opioid 17 99.56 Very High Very High Very High
antagonist 252 99.44 Very High Very High Very High
Potency 20 99.08 Very High Very High Very High
agonist 111 98.68 Very High Very High Very High
rheumatoid arthritis 99 96.88 Very High Very High Very High
metalloproteinase 36 94.64 High High
mu opioid receptor 2 93.28 High High
Disease Link Frequency Relevance Heat
Syndrome 277 99.90 Very High Very High Very High
Cancer 3115 99.84 Very High Very High Very High
Ovarian Cancer 420 99.76 Very High Very High Very High
INFLAMMATION 290 99.68 Very High Very High Very High
Breast Cancer 562 99.16 Very High Very High Very High
Leukemia 40 99.00 Very High Very High Very High
Toxicity 64 98.56 Very High Very High Very High
Colon Cancer 427 98.08 Very High Very High Very High
Metastasis 976 97.68 Very High Very High Very High
Infection 43 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
of the ability of the antibody to block CXCR4 on tumor vasculature [109].
Negative_regulation (block) of CXCR4 in vasculature associated with cancer
1) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.67 Pain Relevance 0.12
CXCR4 protein was also downregulated,
Negative_regulation (downregulated) of CXCR4 protein
2) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.76 Pain Relevance 0
Reduced CXCR4
Negative_regulation (Reduced) of CXCR4
3) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.84 Pain Relevance 0.19
inhibitors of CXCR4 have also been tested in preclinical cancer models.
Negative_regulation (inhibitors) of CXCR4 associated with cancer
4) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.73 Pain Relevance 0.20
debate and may be unrelated to inhibition of CXCR4 as was first presumed.

12.

Negative_regulation (inhibition) of CXCR4
5) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.26 Pain Relevance 0.04
An apparent underestimation of the full complexity of CCRs is well demonstrated in patient 1, in whom a complex karyotype was identified, including an inverted insertion of the MDLS region into the middle SMS-REP/LCR17pB block, two microdeletions (terminal and interstitial in 17p12) and a microduplication involving both SMS and CMT1A chromosome regions.
Negative_regulation (block) of LCR associated with syndrome
6) Confidence 0.57 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.41 Pain Relevance 0
Inhibition of CXCR4 activity reduces intraperitoneal dissemination of ovarian cancer xenografts.
Negative_regulation (Inhibition) of CXCR4 associated with ovarian cancer
7) Confidence 0.44 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.47 Pain Relevance 0.03
signalling leads to downregulation of both VEGF receptor 2 and CXCR4 [142].
Negative_regulation (downregulation) of CXCR4
8) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.25 Pain Relevance 0
The

existence of a mechanism of 15dPGJ2-induced CXCR4 downregulation

Negative_regulation (downregulation) of CXCR4
9) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.45 Pain Relevance 0.23
thiazolidinediones both cause downregulation of CXCR4 mRNA and
Negative_regulation (downregulation) of CXCR4 mRNA
10) Confidence 0.43 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2528256 Disease Relevance 0.90 Pain Relevance 0.22
eliminates cell-surface CXCR4 at a concentration of 10?
Negative_regulation (eliminates) of CXCR4
11) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.22 Pain Relevance 0
persistent suppression of CXCR4 on cancer cells.
Negative_regulation (suppression) of CXCR4 associated with cancer
12) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.65 Pain Relevance 0.11
downregulate CXCR4, although it does not contain the ?
Negative_regulation (downregulate) of CXCR4
13) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.28 Pain Relevance 0.21
PGD2 produces similar downregulation of CXCR4 in other cell
Negative_regulation (downregulation) of CXCR4
14) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.10 Pain Relevance 0
However, blocking the CXCL12/CXCR4
Negative_regulation (blocking) of CXCR4
15) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.37 Pain Relevance 0.05
downregulation of CXCR4 for the J-series prostaglandins are consistent with
Negative_regulation (downregulation) of CXCR4
16) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.14 Pain Relevance 0
glitazone agents also downregulate CXCR4, with a rank order of potency

(rosiglitazone > pioglitazone > ciglitazone > troglitazone) consistent

Negative_regulation (downregulate) of CXCR4 associated with potency
17) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.86 Pain Relevance 0.13
cells that had undergone stable knockdown of CXCR4 did not form tumors or lung
Negative_regulation (knockdown) of CXCR4 in lung associated with cancer
18) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.71 Pain Relevance 0.03
-dependent downregulation of CXCR4 on cancer cells, may slow
Negative_regulation (downregulation) of CXCR4 associated with cancer
19) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.78 Pain Relevance 0.03
known as CXCR4 was cloned in 1994, and was originally given the name leukocyte-expressed
Negative_regulation (given) of CXCR4 in leukocyte
20) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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