INT11313

Context Info Confidence 0.70 First Reported 1991 Last Reported 2010 Negated 16 Speculated 12 Reported most in Abstract Documents 526 Total Number 538 Disease Relevance 331.27 Pain Relevance 201.59

extracellular space (Il6) aging (Il6) extracellular region (Il6)

Anatomy Link Frequency plasma 59 nerve 13 macrophages 12 blood 11 lung 11 Il6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 2590 100.00 cytokine 2041 100.00 Pain 479 100.00 antagonist 280 100.00 anesthesia 214 100.00 Nerve growth factor 146 100.00 allodynia 145 100.00 Angina 137 100.00 Inflammatory mediators 126 100.00 Dorsal horn 99 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 3013 100.00 Cancer 881 100.00 Injury 813 100.00 Stress 646 100.00 Neuropathic Pain 644 100.00 Nervous System Injury 590 100.00 Necrosis 238 100.00 Myocardial Infarction 138 100.00 Cv General 3 Under Development 120 100.00 Asthma 54 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Abnormal EEG activities were observed in all infected rats under anesthesia, including high voltage EEG burst amplitude and increased EEG spikes in the early phase (8 h-day 2) of infection, and these increases at the early phase were in parallel with a significant increase level of interleukin-6 (IL-6) in the serum.

Positive_regulation (increase) of IL-6 in spikes associated with anesthesia and infection

1) Confidence 0.70 Published 2010 Journal Neuroscience Section Abstract Doc Link 19892004 Disease Relevance 1.45 Pain Relevance 0.18

In adrenalectomized animals, morphine administration did not increase IL-6 levels, whereas in adrenal demedullated animals, the effect of morphine remained intact.

Neg (not) Positive_regulation (increase) of IL-6 associated with morphine

2) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.99

Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland.

Positive_regulation (elevation) of interleukin-6 in plasma associated with morphine

3) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.82

A rapid and significant (2-fold) increase in plasma IL-6 was observed after morphine administration (10 mg/kg s.c.) to rats.

Positive_regulation (increase) of IL-6 in plasma associated with morphine

4) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.90

In the present study, experiments were designed to address the potential role of central opioid receptors, peripheral autonomic ganglia, and activation of the adrenals in the elevation of plasma IL-6 after morphine administration.

Positive_regulation (elevation) of IL-6 in plasma associated with opioid receptor and morphine

5) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.82

Collectively, these data suggest a unique mechanism by which stimulation of central opioid receptors results in the elevation of plasma IL-6 through autonomic activation specifically of the adrenal cortex.

Positive_regulation (elevation) of IL-6 in autonomic associated with opioid receptor

6) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.75

It has been previously shown that morphine increases serum interleukin-6 (IL-6) levels; however, the mechanism by which this effect is produced is unknown.

Positive_regulation (increases) of interleukin-6 associated with morphine

7) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.62

It has been previously shown that morphine increases serum interleukin-6 (IL-6) levels; however, the mechanism by which this effect is produced is unknown.

Positive_regulation (increases) of IL-6 associated with morphine

8) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.63

Pretreatment with a ganglionic blocker, chlorisondamine (0.5 mg/kg i.p.), also blocked the elevation of IL-6 by morphine, suggesting a role of the autonomic nervous system.

Positive_regulation (elevation) of IL-6 in autonomic nervous system associated with morphine

9) Confidence 0.70 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 1.01

After exposure to the open field, rats not treated with beta-blockers responded with a rapid rise in Tb measured by biotelemetry as well as with an increase in plasma IL-6 activity.

Positive_regulation (increase) of IL-6 in plasma associated with beta blocker

10) Confidence 0.70 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8738584 Disease Relevance 0.05 Pain Relevance 0.19

Beta-adrenoceptor antagonists suppress elevation in body temperature and increase in plasma IL-6 in rats exposed to open field.

Positive_regulation (increase) of IL-6 in plasma associated with antagonist

11) Confidence 0.70 Published 1996 Journal Neuroendocrinology Section Title Doc Link 8738584 Disease Relevance 0.09 Pain Relevance 0.19

In the present study we found a sustained increase in plasma corticosterone both after single and repeated injection of morphine in control and AA rats and an increase of the level of circulating IL-6 in AA rats after repeated injection of morphine.

Positive_regulation (increase) of IL-6 in plasma associated with arthritis and morphine

12) Confidence 0.70 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11220497 Disease Relevance 1.15 Pain Relevance 1.13

Interleukin-6 (IL-6) is markedly upregulated in the peripheral and central nervous systems following nerve injury; however, the functional effects of this are unclear.

Positive_regulation (upregulated) of Interleukin-6 in nerve associated with nervous system injury

13) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14744602 Disease Relevance 0.49 Pain Relevance 0.03

Interleukin-6 (IL-6) is markedly upregulated in the peripheral and central nervous systems following nerve injury; however, the functional effects of this are unclear.

Positive_regulation (upregulated) of IL-6 in nerve associated with nervous system injury

14) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14744602 Disease Relevance 0.49 Pain Relevance 0.03

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.

Positive_regulation (Increase) of interleukin-6 in spinal cord associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord

15) Confidence 0.70 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9813345 Disease Relevance 0.61 Pain Relevance 0.54

Various types of orthopaedic operations lead to an increase in IL-6 serum levels [28,33].

Positive_regulation (increase) of IL-6

16) Confidence 0.70 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.12 Pain Relevance 0.25

In peripheral nerve injury models, IL-6 and IL-6R are increased at the injured nerve and the respective dorsal root ganglion.

Positive_regulation (increased) of IL-6 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury and peripheral nerve injury

17) Confidence 0.70 Published 2005 Journal Cytokine Section Abstract Doc Link 15863388 Disease Relevance 0.46 Pain Relevance 0.41

IL-6 is increased at the ipsilateral dorsal and ventral horn of the spinal cord.

Positive_regulation (increased) of IL-6 in dorsal associated with spinal cord

18) Confidence 0.70 Published 2005 Journal Cytokine Section Abstract Doc Link 15863388 Disease Relevance 0.47 Pain Relevance 0.46

Central injection of morphine is also able to increase circulating IL-6 concentration in control animals.

Positive_regulation (increase) of IL-6 associated with morphine

19) Confidence 0.70 Published 1999 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 10503733 Disease Relevance 0.89 Pain Relevance 0.62

Central injection of morphine stimulates plasma corticosterone and interleukin (IL)-6 and IL-6 R mRNAs in the pituitary and adrenals in adjuvant-induced arthritis.

Positive_regulation (stimulates) of IL-6 in pituitary associated with arthritis and morphine

20) Confidence 0.70 Published 1999 Journal J. Biol. Regul. Homeost. Agents Section Title Doc Link 10503733 Disease Relevance 0.96 Pain Relevance 0.62

General Comments

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