INT113137

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 0.89
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
neuronal 1
neurons 1
brain 1
striatum 1
midbrain 1
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 21 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Dopamine 138 99.80 Very High Very High Very High
Morphine 32 99.16 Very High Very High Very High
opioid receptor 2 98.60 Very High Very High Very High
GABAergic 39 97.36 Very High Very High Very High
gABA 48 96.64 Very High Very High Very High
interneuron 11 96.04 Very High Very High Very High
Opioid 2 94.48 High High
midbrain 4 93.96 High High
Disease Link Frequency Relevance Heat
Adhesions 7 95.52 Very High Very High Very High
Targeted Disruption 62 90.00 High High
Anxiety Disorder 6 58.72 Quite High
Apoptosis 5 49.28 Quite Low
Neurological Disease 1 44.04 Quite Low
Sprains And Strains 15 35.32 Quite Low
Frailty 2 32.72 Quite Low
Stress 3 17.68 Low Low
Depression 33 10.32 Low Low
Urological Neuroanatomy 2 8.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors.
Positive_regulation (activation) of DARPP-32 in striatum associated with opioid receptor
1) Confidence 0.65 Published 2010 Journal Addict Biol Section Title Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.30
Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine reward.
Positive_regulation (Activation) of DARPP-32 associated with morphine
2) Confidence 0.46 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 17251906 Disease Relevance 0.13 Pain Relevance 0.78
These results demonstrate that dopamine D1 receptor-mediated activation of the cAMP/DARPP-32 cascade in striatal medium spiny neurons is involved in the psychomotor action, but not in the rewarding properties, of morphine.
Positive_regulation (activation) of DARPP-32 in neurons associated with dopamine and morphine
3) Confidence 0.40 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17251906 Disease Relevance 0.16 Pain Relevance 0.97
Bilateral analyses of pTH, TH, and pDARPP-32 for one brain section per region were conducted using an Olympus BX61 microscope fitted with an Olympus FV II digital camera, connected to a PC compatible computer.
Positive_regulation (conducted) of pDARPP-32 in brain
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.11
Elevated pDARPP-32 levels with neglect are also of interest because progesterone can affect [61], suggesting the possibility that altered steroid signaling contributes to neglect.
Positive_regulation (Elevated) of pDARPP-32
5) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.33
The small proportion of weak EGFP neurons that were negative for DARPP-32 were always identified as cholinergic interneurons, as shown by colabeling for ChAT (Fig. 5A, B, type 3) [30].
Positive_regulation (negative) of DARPP-32 in interneurons
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.25 Pain Relevance 0
Recently, we reported that mGluR1 activity supports RP induction by facilitating the PKA/phospho-DARPP-32/PP-1 inhibition pathway (Sugiyama et al, 2008).
Positive_regulation (facilitating) of phospho-DARPP-32
7) Confidence 0.21 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.16 Pain Relevance 0.12
In summary, sustained CaMKII activation and GABAAR phosphorylation were accompanied by long-term decreases in the amounts of active PP-1 and PDE1 (Figure 2E and J), and by sustained increases in the amounts of phospho-DARPP-32, cAMP, and active PKA (Figure 2A, B, and G–I).
Positive_regulation (increases) of phospho-DARPP-32
8) Confidence 0.20 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.04
Calcineurin-mediated DARPP-32 dephosphorylation and PP-1 activation is a feedforward inhibitory pathway to CaMKII activation.
Positive_regulation (activation) of DARPP-32
9) Confidence 0.20 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Indeed, in its activated state as pThr34-DARPP-32, it becomes a robust inhibitor of protein phosphatase 1 (PP-1), a substrate responsible for de-phosphorylation of numerous cellular targets.
Positive_regulation (activated) of pThr34-DARPP-32
10) Confidence 0.19 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.27
On the one hand, the phosphorylation on Thr34 by protein kinase A (PKA) converts DARPP-32 into a selective inhibitor of serine/threonine protein phosphatase-1 (PP-1), thereby enhancing phosphorylation of proteins targeted by PP-1.
Positive_regulation (converts) of DARPP-32
11) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.12 Pain Relevance 0.14
Intermittent morphine treatment results in the upregulation of dopamine receptor-regulated G-protein activation in the mouse limbic forebrain, whereas this treatment causes the downregulation of GABA(B) receptor function to activate G-protein in the mouse lower midbrain.
Positive_regulation (activation) of dopamine receptor-regulated in midbrain associated with gaba, dopamine receptor, midbrain and morphine
12) Confidence 0.11 Published 2003 Journal Addict Biol Section Abstract Doc Link 13129834 Disease Relevance 0 Pain Relevance 0.94
These cells were also negative for various striatal markers such as Ebf1 or enkephalin mRNAs and calbindin, DARPP32 and dopamine 2 receptor, suggesting that they are unable to differentiate (Colombo et al., 2007).
Positive_regulation (negative) of DARPP32 associated with dopamine and enkephalin
13) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.18
This procedure has been previously demonstrated to yield a high proportion of neuronal cells expressing MSN markers (e.g. 95–98% of NeuN-positive cells express high levels of DARPP-32) and exhibiting an electrophysiologic behavior characteristic of GABAergic neurons [21].
Positive_regulation (levels) of DARPP-32 in neuronal associated with gabaergic
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.05

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