INT113147

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.24
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Acta2) cytoplasm (Acta2)
Anatomy Link Frequency
smooth muscle 3
PSC 2
muscle 1
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 19 98.00 Very High Very High Very High
fibrosis 7 94.96 High High
alcohol 4 91.12 High High
cytokine 4 84.32 Quite High
COX-2 inhibitor 1 70.88 Quite High
Inflammation 4 69.72 Quite High
addiction 2 50.00 Quite Low
Inflammatory response 1 48.84 Quite Low
agonist 6 34.88 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 13 99.16 Very High Very High Very High
Pancreatitis 21 98.00 Very High Very High Very High
Shock 151 96.92 Very High Very High Very High
Injury 7 95.76 Very High Very High Very High
Fibrosis 10 94.96 High High
Hyalinosis 4 87.92 High High
Disease 6 80.32 Quite High
Stress 23 79.48 Quite High
Malignant Neoplastic Disease 43 77.04 Quite High
Cancer 70 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRF plays a prominent role in regulating the expression of heart muscle genes [33] and may explain increases in muscle contraction genes (ACTA1, ACTA2, DES, MYL1, MYL2, MYL3, MYL9, MYOM1, TNNC2, TNNT1, TNNT3, TPM2, TPM4) after HS.
Positive_regulation (increases) of ACTA2 in muscle associated with shock
1) Confidence 0.34 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.68 Pain Relevance 0
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Positive_regulation (increased) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
2) Confidence 0.24 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.30 Pain Relevance 0.71
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Positive_regulation (increased) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis
3) Confidence 0.19 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.28 Pain Relevance 0.68
Engrafted MSC in liver express alpha smooth muscle actin and their localization merges with collagen deposition
Positive_regulation (Engrafted) of alpha smooth muscle actin in smooth muscle
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.09 Pain Relevance 0.05
Greater than 70% are positive for smooth muscle actin (SMA), and almost half are positive for desmin [8].
Positive_regulation (positive) of smooth muscle actin in smooth muscle
5) Confidence 0.01 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 0.54 Pain Relevance 0
METHODS: To test the hypothesis that pancreatic duct obstruction activates PSCs, clinical and experimental analyses were performed using alpha smooth muscle actin (alpha-SMA) as a marker of their activation.
Spec (analyses) Positive_regulation (using) of alpha-SMA in smooth muscle
6) Confidence 0.01 Published 2003 Journal J. Surg. Res. Section Body Doc Link 13678692 Disease Relevance 0 Pain Relevance 0
Anti-TGF-beta neutralizing antibody also attenuated the increase in COX-2 and alpha-SMA expression caused by IL-1beta and IL-6.
Positive_regulation (increase) of alpha-SMA
7) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.34 Pain Relevance 0.22

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