INT113151

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.80
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Anatomy Link Frequency
cornea 3
mesenchyme 1
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 97.08 Very High Very High Very High
MU agonist 1 93.64 High High
Opioid 6 92.88 High High
tramadol 9 92.08 High High
Potency 1 84.48 Quite High
anticonvulsant 7 75.00 Quite High
antagonist 16 69.52 Quite High
narcan 2 68.48 Quite High
gABA 8 55.12 Quite High
Neurotransmitter 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Shock 184 100.00 Very High Very High Very High
Convulsion 9 100.00 Very High Very High Very High
Burns 18 97.92 Very High Very High Very High
Aplasia 1 87.40 High High
Wound Healing 8 83.28 Quite High
Corneal Neovascularization 18 82.80 Quite High
Cancer 13 82.76 Quite High
Skin Cancer 3 82.08 Quite High
Malignant Neoplastic Disease 6 80.92 Quite High
Injury 21 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shh, but not the Ptc receptor, was upregulated in a vascularized healing mouse cornea post-alkali burn.
Positive_regulation (upregulated) of Ptc receptor in cornea associated with burns
1) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.17 Pain Relevance 0
We previously reported that Shh but not the Ptc Shh receptor is upregulated in the healing rat corneal epithelium post-debridement and that Shh promotes cell proliferation in the healing epithelium of a mouse cornea [14].
Positive_regulation (upregulated) of Ptc in cornea
2) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.58 Pain Relevance 0.03
Analyses of activated IHH signaling in C3H10T1/2 cells showed that three BDA1-associated mutations (p.E95K, p.D100E and p.E131K) severely impaired the induction of targets such as Ptch1 and Gli1.
Positive_regulation (induction) of Ptch1
3) Confidence 0.55 Published 2010 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 20024692 Disease Relevance 0.09 Pain Relevance 0.07
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Positive_regulation (upregulated) of Ptc in cornea associated with cytokine
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.23 Pain Relevance 0.08
In turn, epithelial Shh signals to the underneath mesenchyme where target genes like Gli1 and Ptc are induced [23].
Positive_regulation (induced) of Ptc in mesenchyme
5) Confidence 0.37 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
To clarify the action of HS and MES on Akt activation, we determined their time-dependent effect.
Positive_regulation (activation) of MES associated with shock
6) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.05 Pain Relevance 0
MES seizures were induced via transauricular electrodes (60 mA, 0.2 sec).
Positive_regulation (induced) of MES associated with convulsion
7) Confidence 0.23 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16140368 Disease Relevance 0.29 Pain Relevance 0.81
Knockdown of Hsp72 by siRNA in these cells reduced the effect of HS+MES (Fig. 9F), suggesting that the effect of HS+MES is partly mediated by Hsp72.
Positive_regulation (effect) of MES associated with shock
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.93 Pain Relevance 0
MES seizures were induced via transauricular electrodes (60 mA, 0.2 s).
Positive_regulation (induced) of MES associated with convulsion
9) Confidence 0.14 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 13679223 Disease Relevance 0.45 Pain Relevance 0.42

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