INT113153

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.11
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
CeA 3
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 3 99.98 Very High Very High Very High
Pain 89 99.80 Very High Very High Very High
Arthritis 40 99.48 Very High Very High Very High
amygdala 82 99.24 Very High Very High Very High
antagonist 41 99.20 Very High Very High Very High
Cannabinoid receptor 3 99.12 Very High Very High Very High
GABAergic 17 98.74 Very High Very High Very High
Glutamate 9 96.46 Very High Very High Very High
Inflammation 4 94.84 High High
Action potential 5 94.64 High High
Disease Link Frequency Relevance Heat
Arthritis 66 99.48 Very High Very High Very High
Pain 83 98.96 Very High Very High Very High
Nociception 10 98.24 Very High Very High Very High
INFLAMMATION 4 94.84 High High
Injury 3 90.24 High High
Inflammatory Pain 1 86.28 High High
Anxiety Disorder 4 39.40 Quite Low
Frailty 3 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a change of mGluR1 function and activation in the amygdala in pain-related sensitization, whereas mGluR5 is involved in brief as well as prolonged nociception.
Regulation (change) of mGluR1 in amygdala associated with nociception, pain and amygdala
1) Confidence 0.44 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 13679408 Disease Relevance 1.25 Pain Relevance 0.99
Here we address the roles of mGluR1 and mGluR5 subtypes in the CeA in the modulation of supraspinally organized behavioral responses in a model of arthritic pain.
Regulation (roles) of mGluR1 in CeA associated with pain, amygdala and arthritis
2) Confidence 0.38 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 0.95 Pain Relevance 1.03
These findings suggest differential roles of mGluR1 and mGluR5 in the CeA in pain-related vocalizations.
Regulation (roles) of mGluR1 in CeA associated with pain and amygdala
3) Confidence 0.38 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 0.81 Pain Relevance 1.05
Excitatory transmission is under GABAergic inhibition that is lost in arthritis through a mechanism that involves mGluR1.
Regulation (involves) of mGluR1 associated with gabaergic and arthritis
4) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.53 Pain Relevance 0.69
Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.
Regulation (effects) of mGlu1 associated with antagonist and analgesic
5) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Title Doc Link 16793067 Disease Relevance 0.58 Pain Relevance 1.43
Ionotropic receptor channels for glutamate and glycine (GluR5, GluR2 and Glra1) are strongly activated during rhythmic activity such as locomotion [14], whereas some of the metabotropic receptors are know to cause slow modulation of the activity (mGluR1 [86], Gabr2 [87] and Cnr1 [88]).
Regulation (modulation) of mGluR1 associated with glutamate and cannabinoid receptor
6) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.21

General Comments

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