INT113164

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.96
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
inner ear 4
endothelial cell 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 108 100.00 Very High Very High Very High
cINOD 9 100.00 Very High Very High Very High
antidepressant 5 99.20 Very High Very High Very High
depression 3 98.90 Very High Very High Very High
fluoxetine 6 98.20 Very High Very High Very High
sSRI 2 97.94 Very High Very High Very High
Glutamate 74 97.40 Very High Very High Very High
Inflammation 2 96.08 Very High Very High Very High
COX2 3 90.16 High High
ischemia 7 74.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Depression 3 98.90 Very High Very High Very High
Apoptosis 7 98.80 Very High Very High Very High
Thyroid Neoplasm 4 98.68 Very High Very High Very High
Cancer 22 98.00 Very High Very High Very High
Pancreatic Cancer 2 96.56 Very High Very High Very High
Injury 17 95.48 Very High Very High Very High
Renal Cancer 36 94.20 High High
Glaucoma 14 93.20 High High
Drug Induced Neurotoxicity 7 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study therefore examined the effects of EP2 and EP4 agonists on the modulation of inner ear VEGF levels.
Spec (examined) Regulation (effects) of Spec (examined) Regulation (modulation) of VEGF in inner ear associated with agonist
1) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.26 Pain Relevance 0.24
This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and VEGF regulation.
Regulation (role) of Regulation (regulation) of VEGF associated with inflammation and cinod
2) Confidence 0.27 Published 2010 Journal Pancreas Section Abstract Doc Link 20118820 Disease Relevance 0.37 Pain Relevance 0.18
First, by determining the requirement for VEGF in the actions of a 5-HT selective reuptake inhibitor (SSRI), fluoxetine in behavioral models of depression/antidepressant response; and second, by examining the role of the 5-HT1A receptor subtype in the regulation of VEGF, and the cellular localization of antidepressant regulation of VEGF expression.
Spec (examining) Regulation (role) of Regulation (regulation) of VEGF associated with antidepressant, depression, ssri and fluoxetine
3) Confidence 0.24 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 19553916 Disease Relevance 0.18 Pain Relevance 0.60
We thus examined the expression of EP2 in the cochlea, and the effects of local EP2 and EP4 agonist application on the modulation of VEGF in the inner ear.
Spec (examined) Regulation (effects) of Regulation (modulation) of VEGF in inner ear associated with agonist
4) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.52 Pain Relevance 0.23
The function of the vHL is involved in the regulation of the vascular endothelial growth factor (VEGF), and alterations of the gene promote VEGF overexpression and hypervascularization of these tumors [5].
Regulation (involved) of Regulation (alterations) of VEGF associated with cancer
5) Confidence 0.13 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 1.24 Pain Relevance 0
The function of the vHL is involved in the regulation of the vascular endothelial growth factor (VEGF), and alterations of the gene promote VEGF overexpression and hypervascularization of these tumors [5].
Regulation (involved) of Regulation (regulation) of vascular endothelial growth factor associated with cancer
6) Confidence 0.13 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 1.22 Pain Relevance 0
important factors, for instance nitric oxide and VEGF, have to be
Regulation (have) of Regulation (be) of VEGF
7) Confidence 0.07 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 1.01 Pain Relevance 0.37
Based on the experimental data and the literature, the mechanisms by which NSAIDs inhibit angiogenesis appear to be multifactorial and likely include local changes in angiogenic growth factor expression, alteration in key regulators and mediators of vascular endothelial growth factor (VEGF), increased endothelial cell apoptosis, inhibition of endothelial cell migration, recruitment of inflammatory cells and platelets, and/or thromboxane A2 mediated effects.
Regulation (changes) of Regulation (alteration) of VEGF in endothelial cell associated with inflammation, cinod and apoptosis
8) Confidence 0.04 Published 2003 Journal J. Mol. Med. Section Abstract Doc Link 13679997 Disease Relevance 1.17 Pain Relevance 0.81

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