INT11318

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 1985
Last Reported 2011
Negated 9
Speculated 6
Reported most in Abstract
Documents 274
Total Number 281
Disease Relevance 183.82
Pain Relevance 60.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
fibroblast 14
nerve 12
neurons 11
macrophages 9
brain 5
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2031 100.00 Very High Very High Very High
cytokine 1436 100.00 Very High Very High Very High
Nerve growth factor 314 100.00 Very High Very High Very High
ischemia 265 100.00 Very High Very High Very High
metalloproteinase 146 100.00 Very High Very High Very High
withdrawal 86 100.00 Very High Very High Very High
substance P 68 100.00 Very High Very High Very High
Inflammatory mediators 51 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
rheumatoid arthritis 1632 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3950 100.00 Very High Very High Very High
INFLAMMATION 2179 100.00 Very High Very High Very High
Apoptosis 1036 100.00 Very High Very High Very High
Infection 761 100.00 Very High Very High Very High
Hypoxia 280 100.00 Very High Very High Very High
Necrosis 254 100.00 Very High Very High Very High
Cv Unclassified Under Development 241 100.00 Very High Very High Very High
Lifespan 161 100.00 Very High Very High Very High
Osteoporosis 97 100.00 Very High Very High Very High
Stroke 69 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphocytes from animals sensitized to keyhole limpet hemocyanin showed a significantly lower capacity to produce macrophage migration inhibitory factor 8 days after termination of exposure to lidocaine.
Gene_expression (produce) of factor in macrophage associated with lidocaine
1) Confidence 0.52 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3160679 Disease Relevance 0.16 Pain Relevance 0.41
In the hippocampus of untreated P15 Ts65Dn mice, we found normal 5-HT levels but a lower expression of 5-HT1A receptors and brain-derived neurotrophic factor (BDNF).
Gene_expression (expression) of factor in hippocampus associated with hippocampus
2) Confidence 0.52 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.91 Pain Relevance 0.44
Similarly, murine leukemia inhibitory factor produced a greater percentage of neurons (57%) with sensitivity to capsaicin (sensory phenotype) than human leukemia inhibitory factor (3%).
Gene_expression (produced) of factor in neurons associated with leukemia and qutenza
3) Confidence 0.42 Published 1999 Journal J. Neurobiol. Section Abstract Doc Link 10380072 Disease Relevance 0.36 Pain Relevance 0.10
Since 1984, Factor AF2 is 'biotechnologically' produced and as a 'biological response modifier' (BRM) in the oncotherapy distributed by Biosyn Arzneimittel GmbH, Stuttgart.
Gene_expression (produced) of Factor AF2
4) Confidence 0.40 Published 1990 Journal Schweiz. Rundsch. Med. Prax. Section Abstract Doc Link 2349412 Disease Relevance 0.35 Pain Relevance 0.08
However, murine leukemia inhibitory factor (L: 25%, N: 52%, and P: 13%) and ciliary neurotrophic factor (L: 18%, N: 49%, and P: 9%) plus somite cells produced neurons with sensory-like calcium current profiles.
Gene_expression (produced) of factor in ciliary associated with leukemia
5) Confidence 0.37 Published 1999 Journal J. Neurobiol. Section Abstract Doc Link 10380072 Disease Relevance 0.35 Pain Relevance 0.08
However, murine leukemia inhibitory factor (L: 25%, N: 52%, and P: 13%) and ciliary neurotrophic factor (L: 18%, N: 49%, and P: 9%) plus somite cells produced neurons with sensory-like calcium current profiles.
Gene_expression (produced) of factor in ciliary associated with leukemia
6) Confidence 0.37 Published 1999 Journal J. Neurobiol. Section Abstract Doc Link 10380072 Disease Relevance 0.35 Pain Relevance 0.08
Transgenic mice overexpressing nerve growth factor (NGF) or glial cell line-derived neurotrophic factor (GDNF) in the skin possess a greatly increased number of nociceptors.
Gene_expression (overexpressing) of factor in skin associated with targeted disruption, nerve growth factor and nociceptor
7) Confidence 0.32 Published 2005 Journal Pain Section Abstract Doc Link 15661434 Disease Relevance 1.03 Pain Relevance 0.51
Transgenic mice overexpressing nerve growth factor (NGF) or glial cell line-derived neurotrophic factor (GDNF) in the skin possess a greatly increased number of nociceptors.
Gene_expression (overexpressing) of factor in skin associated with targeted disruption, nerve growth factor and nociceptor
8) Confidence 0.32 Published 2005 Journal Pain Section Abstract Doc Link 15661434 Disease Relevance 1.01 Pain Relevance 0.50
The data are interpreted to suggest that over-expression of substance P or some other factor in the spinal cord of transgenic mice is associated with the up-regulation or facilitation of an opiate-mediated intrinsic antinociceptive mechanism.
Gene_expression (expression) of factor in spinal cord associated with targeted disruption, opiate, antinociceptive, spinal cord and substance p
9) Confidence 0.27 Published 2000 Journal Neuroscience Section Abstract Doc Link 10727796 Disease Relevance 0.81 Pain Relevance 1.70
The data are interpreted to suggest that over-expression of substance P or some other factor in the spinal cord of transgenic mice is associated with the up-regulation or facilitation of an opiate-mediated intrinsic antinociceptive mechanism.
Spec (suggest) Gene_expression (over) of factor in spinal cord associated with targeted disruption, opiate, antinociceptive, spinal cord and substance p
10) Confidence 0.27 Published 2000 Journal Neuroscience Section Abstract Doc Link 10727796 Disease Relevance 0.81 Pain Relevance 1.70
The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.
Gene_expression (levels) of factor in macrophage associated with necrosis, cancer and morphine
11) Confidence 0.22 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.61 Pain Relevance 0.78
The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.
Gene_expression (levels) of factor in macrophage associated with necrosis, cancer and morphine
12) Confidence 0.22 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.61 Pain Relevance 0.76
A transgenic mouse has been developed which, during development, over-expresses nerve growth factor under the control of a myelin basic protein promoter.
Gene_expression (over) of factor in nerve associated with targeted disruption and nerve growth factor
13) Confidence 0.16 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199622 Disease Relevance 0.54 Pain Relevance 0.57
Sinomenine protected against the hepatic injuries in the dose range of 10-100 mg/kg in a dose-dependent manner and suppressed the production of tumor necrosis factor (TNF), which appeared in serum earlier than aminotransferases in GalN/LPS-treated mice.
Gene_expression (production) of factor associated with necrosis, cancer and injury
14) Confidence 0.14 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8093093 Disease Relevance 0.47 Pain Relevance 0
The K14-nerve growth factor transgene (sense or antisense) is abundantly expressed in skin from approximately embryonic day 15 and is then constitutively expressed throughout the life of the animal.
Gene_expression (expressed) of factor in nerve associated with nerve growth factor
15) Confidence 0.13 Published 1993 Journal Neuroscience Section Abstract Doc Link 7506820 Disease Relevance 0.62 Pain Relevance 0.69
In light of the fact that systemic administration of nerve growth factor to neonatal or adult rats leads to hyperalgesia, we have asked whether mice expressing the sense K14-nerve growth factor transgene exhibit similar sensory abnormalities and whether mice expressing the antisense nerve growth factor complementary DNA were hypoalgesic.
Gene_expression (expressing) of factor in nerve associated with hyperalgesia, nerve growth factor and congenital anomalies
16) Confidence 0.13 Published 1993 Journal Neuroscience Section Abstract Doc Link 7506820 Disease Relevance 0.63 Pain Relevance 0.81
Modulation of tumor necrosis factor and gamma interferon production by cocaine and morphine in aging mice infected with LP-BM5, a murine retrovirus.
Gene_expression (production) of factor associated with necrosis, aging, cancer, morphine and cocaine
17) Confidence 0.13 Published 1991 Journal J. Leukoc. Biol. Section Title Doc Link 1717622 Disease Relevance 1.20 Pain Relevance 0.72
The effects of cocaine and morphine on gamma-interferon (IFN) and tumor necrosis factor (TNF) production in vivo and with isolated spleen cells were measured by a sandwich enzyme-linked immunosorbent assay (ELISA) method.
Gene_expression (production) of factor in spleen associated with necrosis, cancer, morphine and cocaine
18) Confidence 0.13 Published 1991 Journal J. Leukoc. Biol. Section Abstract Doc Link 1717622 Disease Relevance 1.12 Pain Relevance 0.53
A transgenic mouse has been developed which, during development, over-expresses nerve growth factor under the control of a myelin basic protein promoter.
Gene_expression (expresses) of factor in nerve associated with targeted disruption and nerve growth factor
19) Confidence 0.13 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199622 Disease Relevance 0.54 Pain Relevance 0.57
This modulation could be under the control of unidentified activity-dependent molecular mechanism involving stimuli through the skeletal muscle contraction, inducing in turn, the synthesis of a CA-regulating factor(s) retrogradely transported to the neuronal cell body and/or nuclei.
Gene_expression (synthesis) of factor in cell body
20) Confidence 0.13 Published 1995 Journal Brain Res. Section Abstract Doc Link 8974644 Disease Relevance 0.38 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox