INT113186

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 21.06
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
T cells 12
NK cells 9
blood 2
cardiac ventricles 1
macrophages 1
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Patellofemoral syndrome 33 100.00 Very High Very High Very High
rheumatoid arthritis 900 99.48 Very High Very High Very High
Central nervous system 283 98.16 Very High Very High Very High
antagonist 44 95.52 Very High Very High Very High
adenocard 20 94.88 High High
Migraine 2 91.76 High High
chemokine 5 87.40 High High
Inflammation 178 86.48 High High
cytokine 199 86.08 High High
Pain 55 85.68 High High
Disease Link Frequency Relevance Heat
Patellofemoral Pain Syndrome 33 100.00 Very High Very High Very High
Pulmonary Disease 175 99.50 Very High Very High Very High
Rheumatoid Arthritis 900 99.48 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 418 99.24 Very High Very High Very High
Macrophage Activation Syndrome 551 98.96 Very High Very High Very High
Cancer 243 98.88 Very High Very High Very High
Nicotine Addiction 95 98.44 Very High Very High Very High
Apoptosis 148 97.44 Very High Very High Very High
Emphysema 14 97.28 Very High Very High Very High
Systemic Lupus Erythematosus 38 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three activities that typically provoke PFP will be used as a physical measure of function [10].
Gene_expression (provoke) of PFP associated with patellofemoral syndrome
1) Confidence 0.53 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2279129 Disease Relevance 0.68 Pain Relevance 0.41
These data demonstrated that perforin but not FasL expression was necessary for VP2121–130 peptide induced CNS vascular permeability.


Gene_expression (expression) of perforin associated with central nervous system
2) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.14
In light of the discrepancy between past and present findings, we further sought to define the importance of perforin expression in promoting vascular permeability and functional impairment by crossing mice heterozygous for perforin (F1) with C57BL/6 Prf1?
Gene_expression (expression) of perforin
3) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.11
Unlike perforin competent C57BL/6 mice, C57BL/6 Prf1?
Gene_expression (/) of Prf1
4) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.18 Pain Relevance 0.06
Unlike perforin competent C57BL/6 mice, C57BL/6 Prf1?
Gene_expression (competent) of perforin
5) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.18 Pain Relevance 0.04
Astrocyte activation is dependant on perforin expression
Gene_expression (expression) of perforin in Astrocyte
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.10
As a further step to understand the physiological role(s) of NL1 in mouse, we mapped NL1 mRNA expression pattern in embryos and in young animals at postnatal days p1 and p3, and in adult nervous tissue, using in situ hybridization at the cellular level.
Gene_expression (expression) of p1 in nervous tissue
7) Confidence 0.33 Published 2003 Journal Peptides Section Abstract Doc Link 14499288 Disease Relevance 0.26 Pain Relevance 0.23
The exact mechanisms that would link deficient NK cell function and, in some cases, depressed perforin expression with the expansion of activated macrophages are not clear.
Gene_expression (expression) of perforin in macrophages
8) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.43 Pain Relevance 0.13
Perforin expression
Gene_expression (expression) of Perforin
9) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.38 Pain Relevance 0.18
Other groups have noted low levels of perforin expression in cytotoxic cells from patients with sJRA in comparison with other clinical forms of the disease, suggesting that this feature might be responsible for the increased incidence of MAS [26,27].
Gene_expression (expression) of perforin associated with macrophage activation syndrome and disease
10) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.20 Pain Relevance 0.14
Because reduced perforin expression in cytotoxic effector cells has previously been reported in sJRA [26,27], we assessed perforin content and relative proportions of perforin-positive NK cells, CD8+ lymphocytes, and NK T cells.
Gene_expression (expression) of perforin in NK cells
11) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.38 Pain Relevance 0.18
Although no overall correlation between perforin expression and NK cell cytolytic activty was noted in our study, we still cannot exclude the possibility that, at least in some patients, reduced perforin expression might have functional significance.
Gene_expression (expression) of perforin in NK cell
12) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.81 Pain Relevance 0.11
These cells express low levels of perforin and are, in general, poorly cytotoxic [24].
Gene_expression (express) of perforin
13) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.52 Pain Relevance 0.13
Although no overall correlation between perforin expression and NK cell cytolytic activty was noted in our study, we still cannot exclude the possibility that, at least in some patients, reduced perforin expression might have functional significance.
Gene_expression (expression) of perforin in NK cell
14) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.78 Pain Relevance 0.11
The ethnic heterogeneity of the patients with JRA included in this study might also underlie the discrepancy between our results and the study by Wulffraat and colleagues [26], which showed that patients with sJRA as a group had lower perforin expression in cytotoxic effector lymphocytes.
Gene_expression (expression) of perforin in lymphocytes associated with rheumatoid arthritis
15) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.48 Pain Relevance 0.10
+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry.
Gene_expression (expression) of perforin in T cells
16) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.39 Pain Relevance 0.31
In our study, when patients with sJRA were analyzed as a group, perforin levels were not significantly different from those in patients with other JRA types.
Gene_expression (levels) of perforin associated with rheumatoid arthritis
17) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.25 Pain Relevance 0.15
Some decrease in perforin expression in NK cells and cytotoxic T lymphocytes was seen in patients within each of the JRA groups with no statistically significant differences.
Gene_expression (expression) of perforin in cytotoxic T lymphocytes associated with rheumatoid arthritis
18) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.26 Pain Relevance 0.32
Because perforin is a protein that mediates the cytotoxic activity of NK cells, we assessed whether decreased perforin expression might have contributed to the development of NK dysfunction in JRA.
Gene_expression (expression) of perforin in NK cells associated with rheumatoid arthritis
19) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.43 Pain Relevance 0.15
The main purpose of this cross-sectional study was to characterize numbers of circulating NK cells, their cytolytic activity, CD56bright : CD56dim subset ratio, and perforin/granzyme B expression in the major cytotoxic cell populations in patients with different clinical forms of JRA.


Gene_expression (expression) of perforin in NK cells associated with rheumatoid arthritis
20) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.37 Pain Relevance 0.27

General Comments

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