INT113203

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.50
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
spinal 2
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 2 99.28 Very High Very High Very High
cytokine 17 98.48 Very High Very High Very High
Inflammatory response 5 98.22 Very High Very High Very High
allodynia 2 98.04 Very High Very High Very High
antagonist 33 94.48 High High
Peripheral nerve injury 4 92.80 High High
Kinase C inhibitor 2 90.96 High High
Cannabinoid 81 86.48 High High
Neuropathic pain 8 85.20 High High
intrathecal 2 79.48 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 372 100.00 Very High Very High Very High
Cancer 284 100.00 Very High Very High Very High
Nervous System Injury 22 99.48 Very High Very High Very High
Primary Sclerosing Cholangitis 44 99.44 Very High Very High Very High
Hyperalgesia 2 99.28 Very High Very High Very High
Neuropathic Pain 10 98.04 Very High Very High Very High
INFLAMMATION 97 98.02 Very High Very High Very High
Apoptosis 15 96.96 Very High Very High Very High
Death 6 89.60 High High
Necrosis 3 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar analyses were performed in order to evaluate the role of the CB1 receptors in the effects of WIN on the acquisition and reinstatement of the MDMA-induced CPP.
Regulation (role) of WIN
1) Confidence 0.34 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0 Pain Relevance 0.04
Finally, at 7 days, the top networks are focused on immunomodulation and inflammatory responses (up-regulation of NPPA/ANP and Brca1 - Figure 5A), and continued cell proliferation (up-regulation of Birc5, Foxm1, Cdc2, Ccnb1 and Ccna2 - Figure 5B).


Regulation (regulation) of Foxm1 associated with inflammatory response
2) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.42 Pain Relevance 0.21
Importantly, the CCI-induced upregulation of spinal CB1Rs enhanced the effects of Win 55,212-2 on both thermal hyperalgesia and mechanical allodynia, since inhibition of the CB1R upregulation by PD98059 resulted in a significant reduction of the effects of Win 55,212-2 in CCI rats.
Regulation (effects) of Win in spinal associated with nervous system injury, allodynia and thermal hyperalgesia
3) Confidence 0.07 Published 2003 Journal Pain Section Abstract Doc Link 14499445 Disease Relevance 1.16 Pain Relevance 0.88
Importantly, the CCI-induced upregulation of spinal CB1Rs enhanced the effects of Win 55,212-2 on both thermal hyperalgesia and mechanical allodynia, since inhibition of the CB1R upregulation by PD98059 resulted in a significant reduction of the effects of Win 55,212-2 in CCI rats.
Regulation (effects) of Win in spinal associated with nervous system injury, allodynia and thermal hyperalgesia
4) Confidence 0.07 Published 2003 Journal Pain Section Abstract Doc Link 14499445 Disease Relevance 1.00 Pain Relevance 0.77
Specifically, most MPM tumors including stage I (89 out of 105, ~85%) had a score of < 220, which was never associated with normal mesothelial tissue pointing to down-regulation of the TUSC2 protein in MPM.
Regulation (regulation) of MPM associated with lung cancer and cancer
5) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.08 Pain Relevance 0
Specifically, most MPM tumors including stage I (89 out of 105, ~85%) had a score of < 220, which was never associated with normal mesothelial tissue pointing to down-regulation of the TUSC2 protein in MPM.
Regulation (regulation) of MPM associated with lung cancer and cancer
6) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.12 Pain Relevance 0
To assess the effects of WIN treatment of PSC on the secretion of cytokines IL-6, MCP-1 and TGFbeta, cell culture supernatants were subjected to ELISA.
Regulation (effects) of WIN associated with primary sclerosing cholangitis and cytokine
7) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.62 Pain Relevance 0.34
To validate these TUSC2-dependent transcriptional changes we overexpressed TUSC2 in four additional MPM cell lines and performed RT-PCR evaluation of several potential TUSC2 targets.
Regulation (targets) of MPM associated with lung cancer
8) Confidence 0.02 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.54 Pain Relevance 0
To find out whether TUSC2 mRNA expression is modulated in MPM we analyzed its expression in tumors of different histology, stage, and clinical behavior by semi-quantitative RT-PCR.
Spec (whether) Regulation (modulated) of MPM associated with lung cancer and cancer
9) Confidence 0.02 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.55 Pain Relevance 0.12

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