INT113219
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The uncommon A allele is strongly associated with the HLA-A1-B8-DR3-DQ2 haplotype [18], and is also associated with both autoimmune diseases and the high TNF producer phenotype [19]. | |||||||||||||||
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The receptor binds to DR3, DR4, DR5, ER6 and ER8 motifs of the general nuclear receptor binding site, which have been identified in enhancer and promoter regions of some of the genes regulated [reviewed in [1]]. | |||||||||||||||
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Therefore, recruitment to the HRE and activation of DR3- and DR5-dependent transcription by this factor does not involve a direct association with the receptors and appears to require DREAMDNA interactions. | |||||||||||||||
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Also showing the specificity of the binding of DREAM to the DR3 sequence, an anti-DREAM antibody caused a supershift of the DREAM-DR3 retarded band (Figure 1C). | |||||||||||||||
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To test the importance of these interactions in the transactivating effect of DREAM on hormone receptor mediated transcription, we used DREAM with mutations at the LCDs (Figure 6A) and assessed their activity on the DR3-TK and R-140 reporters in HeLa cells. | |||||||||||||||
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Since the affinity of binding of the receptor to the DRE was lower than to a DR3, the CAT activity was also examined after the overexpression of VDR. | |||||||||||||||
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Figure 1E compares binding of VDR and RXR with the DR3 and the DRE. | |||||||||||||||
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Overlap between HLA class II associations has been seen between AIDs, with DR3 also being associated with GD, SLE and HT, therefore, being termed the autoimmunity haplotype (See Table 1 for list of common AID HLA class II associations). | |||||||||||||||
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Therefore, TR3 translocation from the nucleus may initiate the apoptotic cascade in colon cancer cells by stimulating other cytosolic proapoptotic molecules to associate with mitochondria. | |||||||||||||||
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Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease
Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergammaglobulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive treatment. | |||||||||||||||
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Taking into consideration the genetic markers, it has been found that the association between HLA DR3 and AIH-2 is rather weaker than that reported in AIH-1, while an association between HLA DQ2 and AIH-2 has been reported [14,18,33,34]. | |||||||||||||||
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When they bind their specific death receptor, apoptotic signals are transmitted in the cell and a caspase cascade is activated within seconds of ligand binding, inducing apoptosis in a very rapid way. | |||||||||||||||
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The general signaling pathway that is activated through death receptor binding begins with the generation of ceramide, produced by acid sphingomyelinase. | |||||||||||||||
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