INT113221

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 5.24
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNFRSF25) signal transduction (TNFRSF25) extracellular region (TNFRSF25)
plasma membrane (TNFRSF25)
Anatomy Link Frequency
colon 1
Nucleus 1
TNFRSF25 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 12 90.44 High High
cINOD 3 86.16 High High
Inflammation 18 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 60 100.00 Very High Very High Very High
Apoptosis 54 99.48 Very High Very High Very High
Colon Cancer 12 98.84 Very High Very High Very High
Necrosis 6 91.40 High High
Cancer 6 91.04 High High
INFLAMMATION 21 84.72 Quite High
Hyperplasia 15 46.32 Quite Low
Stress 15 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFRSF25, also called death receptor 3 (DR3), induces NF?
Localization (called) of death receptor 3 associated with death
1) Confidence 0.57 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.87 Pain Relevance 0.04
TNFRSF25, also called death receptor 3 (DR3), induces NF?
Localization (called) of DR3 associated with death
2) Confidence 0.57 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.87 Pain Relevance 0.04
TNFRSF25, also called death receptor 3 (DR3), induces NF?
Localization (called) of TNFRSF25 associated with death
3) Confidence 0.57 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.87 Pain Relevance 0.05
We identified a potential role for BAX recruitment to the mitochondria, secondary to cytoplasmic translocation of TR3, in inducing cytochrome c release and in mediating apoptosis.
Localization (translocation) of TR3 associated with apoptosis
4) Confidence 0.32 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.94 Pain Relevance 0.08
Nucleus-to-cytoplasm translocation of a green fluorescent protein-TR3 construct, but not its direct mitochondrial targeting, was associated with apoptosis induced by the short-chain fatty acid, butyrate.
Localization (translocation) of TR3 in Nucleus associated with apoptosis
5) Confidence 0.32 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.78 Pain Relevance 0.09
Therefore, TR3 translocation from the nucleus may initiate the apoptotic cascade in colon cancer cells by stimulating other cytosolic proapoptotic molecules to associate with mitochondria.
Localization (translocation) of TR3 in colon associated with colon cancer and apoptosis
6) Confidence 0.32 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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