INT113223

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.39
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) signal transducer activity (MC1R) cell-cell signaling (POMC)
cytoplasm (POMC) pigmentation (MC1R) extracellular space (POMC)
Anatomy Link Frequency
melanocyte 4
POMC (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 52 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
antagonist 6 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Cancer 24 84.60 Quite High
Freckles 4 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MC1R is regulated by the physiological agonists alpha-melanocyte-stimulating hormone (alphaMSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP).
adrenocorticotropic hormone Regulation (regulated) of MC1R in melanocyte associated with melanocortin 1 receptor, antagonist and agonist
1) Confidence 0.68 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.08 Pain Relevance 0.86
The MC1R is regulated by the physiological agonists alpha-melanocyte-stimulating hormone (alphaMSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP).
alpha-melanocyte-stimulating hormone Regulation (regulated) of MC1R in melanocyte associated with melanocortin 1 receptor, antagonist and agonist
2) Confidence 0.59 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.08 Pain Relevance 0.85
Interestingly, alpha-MSH is predicted to only have a kinetic effect on the MC-1-R and beta-MSH has even a weaker affinity for the MC-1-R than alpha-MSH.
alpha-MSH Regulation (effect) of MC-1-R
3) Confidence 0.39 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06
The MC1R is regulated by the physiological agonists alpha-melanocyte-stimulating hormone (alphaMSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP).
ACTH Regulation (regulated) of MC1R in melanocyte associated with melanocortin 1 receptor, antagonist and agonist
4) Confidence 0.30 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.13 Pain Relevance 0.86
The MC1R is regulated by the physiological agonists alpha-melanocyte-stimulating hormone (alphaMSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP).
alphaMSH Regulation (regulated) of MC1R in melanocyte associated with melanocortin 1 receptor, antagonist and agonist
5) Confidence 0.30 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.08 Pain Relevance 0.85
Our study further shows that MSH regulates Mc1r function at both the mRNA and protein levels, whereas ASP acts only on its translation.
MSH Regulation (regulates) of Mc1r associated with melanocortin 1 receptor
6) Confidence 0.06 Published 2003 Journal FASEB J. Section Abstract Doc Link 14500544 Disease Relevance 0 Pain Relevance 0.74

General Comments

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