INT113234

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.54
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) signal transduction (Tacr1) plasma membrane (Tacr1)
nucleus (Pax3) DNA binding (Pax3) cytoplasm (Tacr1)
Anatomy Link Frequency
T cells 2
inhibitory interneurons 1
spinal cord dorsal horn 1
Pax3 (Mus musculus)
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 184 100.00 Very High Very High Very High
Spinal cord 24 97.80 Very High Very High Very High
Dorsal horn 20 97.32 Very High Very High Very High
Pain 40 94.96 High High
projection neuron 6 94.32 High High
cINOD 10 93.04 High High
potassium channel 2 93.04 High High
gABA 6 91.20 High High
Glutamate 40 90.84 High High
Action potential 6 81.48 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 4 100.00 Very High Very High Very High
Pain 32 94.96 High High
Nociception 22 93.24 High High
INFLAMMATION 8 91.60 High High
Colitis 10 88.56 High High
Targeted Disruption 6 75.00 Quite High
Sprains And Strains 2 58.84 Quite High
Mucositis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In lamina V, SP binds pertussis toxin-sensitive Gi/Go-coupled NK1R on inhibitory interneurons, which leads to a cascade of downstream events that may result in changes in the activity of non-selective cation channels or inwardly rectifying potassium channels [12] ultimately leading to GABA and/or glycine release.
SP Binding (binds) of NK1R in inhibitory interneurons associated with gaba, bordatella infection, potassium channel and substance p
1) Confidence 0.12 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.48 Pain Relevance 1.22
The final targets for the signaling pathway initiated by SP binding to NK1R to result in SP-driven feed-forward inhibition in the spinal cord dorsal horn are still a mystery. (3) Although SP and NKA are synthesized together, they affect spinal nociception in different ways [24, 25].
SP Binding (binding) of NK1R in spinal cord dorsal horn associated with nociception, dorsal horn, spinal cord and substance p
2) Confidence 0.10 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.09 Pain Relevance 0.71
Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-gamma production.
SP Binding (interacts) of neurokinin 1 receptor in T cells associated with substance p
3) Confidence 0.06 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.48 Pain Relevance 0.50
Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-gamma production.
SP Binding (interacts) of NK-1R in T cells associated with substance p
4) Confidence 0.06 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.48 Pain Relevance 0.50

General Comments

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