INT113242

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, OPRM1) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
intracellular (TNF) extracellular matrix organization (TNF) signal transducer activity (OPRM1)
Anatomy Link Frequency
macrophages 2
TNF (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 10 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
Opioid 4 99.92 Very High Very High Very High
cytokine 2 99.76 Very High Very High Very High
Inflammation 3 99.56 Very High Very High Very High
Endogenous opioid 1 95.24 Very High Very High Very High
IPN 1 90.88 High High
Morphine 1 67.84 Quite High
narcan 1 62.00 Quite High
Potency 1 43.16 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
INFLAMMATION 3 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 96.08 Very High Very High Very High
Leukemia 1 91.36 High High
Inflammatory Pain 1 90.88 High High
Infection 1 84.00 Quite High
Opiate Addiction 1 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of gp120 to macrophages stimulates the cells to release various pro-inflammatory cytokines, including TNF-alpha, which has been shown to regulate transcription of the MOR gene.
TNF-alpha Regulation (regulate) of Transcription (transcription) of MOR in macrophages associated with inflammation, mu opioid receptor and cytokine
1) Confidence 0.45 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.70 Pain Relevance 0.66
The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene.
tumor necrosis factor Regulation (regulated) of Transcription (transcription) of mu-opioid receptor gene associated with necrosis, cancer and opioid receptor
2) Confidence 0.30 Published 2003 Journal Mol. Pharmacol. Section Title Doc Link 14500744 Disease Relevance 0.82 Pain Relevance 0.52

General Comments

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